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Int. J. Mol. Sci. 2014, 15(3), 3624-3639; doi:10.3390/ijms15033624
Article

Anthelmintic Activities of Aporphine from Nelumbo nucifera Gaertn. cv. Rosa-plena against Hymenolepis nana

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Received: 19 December 2013; in revised form: 8 February 2014 / Accepted: 10 February 2014 / Published: 27 February 2014
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: Nelumbo nucifera Gaertn. cv. Rosa-plena (Nelumbonaceae), commonly known as lotus, is a perennial aquatic plant grown and consumed throughout Asia. All parts of N. nucifera have been used for various medicinal purposes in oriental medicine. From the leaves of Nelumbo nucifera Gaertn. cv. Rosa-plena (an aquatic plant), liriodenine (1), lysicamine (2), (-)-anonaine (3), (-)-asimilobine (4), (-)-caaverine (5), (-)-N-methylasimilobine (6), (-)-nuciferine (7), (-)-nornuciferine (8), (-)-roemerine (9), 7-hydroxydehydronuciferine (10) and cepharadione B (11) were isolated and identification and anthelmintic activities of aporphine was evaluated against Anisakis simplex and Hymenolepis nana. This study found that the above constituents killed H. nana or reduced their spontaneous movements (oscillation/peristalsis). However, the above constituents at various concentrations demonstrated no larvicidal effect or ability to halt spontaneous parasite movement for 72 h against A. simplex, respectively. In addition, according to an assay of cestocidal activity against H. nana and nematocidal activity against A. simplex, we found that the above compounds showed greater lethal efficacy on H. nana than against A. simplex. Further investigation showed that these above constituents have effects against peroxyl radicals under cestocidal effect. Together, these findings suggest that these constituents of Nelumbo nucifera Gaertn. cv. Rosa-plena might be used as anthelmintic agents against H. nana.
Keywords: Nelumbo nucifera Gaertn; aporphine; Hymenolepis nana; Anisakis simplex; anthelmintic activity; peroxyl radical Nelumbo nucifera Gaertn; aporphine; Hymenolepis nana; Anisakis simplex; anthelmintic activity; peroxyl radical
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lin, R.-J.; Wu, M.-H.; Ma, Y.-H.; Chung, L.-Y.; Chen, C.-Y.; Yen, C.-M. Anthelmintic Activities of Aporphine from Nelumbo nucifera Gaertn. cv. Rosa-plena against Hymenolepis nana. Int. J. Mol. Sci. 2014, 15, 3624-3639.

AMA Style

Lin R-J, Wu M-H, Ma Y-H, Chung L-Y, Chen C-Y, Yen C-M. Anthelmintic Activities of Aporphine from Nelumbo nucifera Gaertn. cv. Rosa-plena against Hymenolepis nana. International Journal of Molecular Sciences. 2014; 15(3):3624-3639.

Chicago/Turabian Style

Lin, Rong-Jyh; Wu, Mei-Hsuan; Ma, Yi-Hsuan; Chung, Li-Yu; Chen, Chung-Yi; Yen, Chuan-Min. 2014. "Anthelmintic Activities of Aporphine from Nelumbo nucifera Gaertn. cv. Rosa-plena against Hymenolepis nana." Int. J. Mol. Sci. 15, no. 3: 3624-3639.


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