Int. J. Mol. Sci. 2014, 15(2), 2327-2345; doi:10.3390/ijms15022327
Article

Characterization and Antioxidant Properties of Six Algerian Propolis Extracts: Ethyl Acetate Extracts Inhibit Myeloperoxidase Activity

1,2email, 2email, 1email, 3email, 3email, 2email, 3email and 2,4,* email
Received: 12 November 2013; in revised form: 18 January 2014 / Accepted: 23 January 2014 / Published: 7 February 2014
(This article belongs to the Section Bioactives and Nutraceuticals)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Because propolis contains many types of antioxidant compounds such as polyphenols and flavonoids, it can be useful in preventing oxidative damages. Ethyl acetate extracts of propolis from several Algerian regions show high activity by scavenging free radicals, preventing lipid peroxidation and inhibiting myeloperoxidase (MPO). By fractioning and assaying ethyl acetate extracts, it was observed that both polyphenols and flavonoids contribute to these activities. A correlation was observed between the polyphenol content and the MPO inhibition. However, it seems that kaempferol, a flavonoid, contributes mainly to the MPO inhibition. This molecule is in a high amount in the ethyl acetate extract and demonstrates the best efficiency towards the enzyme with an inhibiting concentration at 50% of 4 ± 2 µM.
Keywords: propolis; oxidative stress; free radical scavenging; myeloperoxidase inhibition; LDL oxidation inhibition
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MDPI and ACS Style

Boufadi, Y.M.; Soubhye, J.; Riazi, A.; Rousseau, A.; Vanhaeverbeek, M.; Nève, J.; Boudjeltia, K.Z.; Van Antwerpen, P. Characterization and Antioxidant Properties of Six Algerian Propolis Extracts: Ethyl Acetate Extracts Inhibit Myeloperoxidase Activity. Int. J. Mol. Sci. 2014, 15, 2327-2345.

AMA Style

Boufadi YM, Soubhye J, Riazi A, Rousseau A, Vanhaeverbeek M, Nève J, Boudjeltia KZ, Van Antwerpen P. Characterization and Antioxidant Properties of Six Algerian Propolis Extracts: Ethyl Acetate Extracts Inhibit Myeloperoxidase Activity. International Journal of Molecular Sciences. 2014; 15(2):2327-2345.

Chicago/Turabian Style

Boufadi, Yasmina M.; Soubhye, Jalal; Riazi, Ali; Rousseau, Alexandre; Vanhaeverbeek, Michel; Nève, Jean; Boudjeltia, Karim Z.; Van Antwerpen, Pierre. 2014. "Characterization and Antioxidant Properties of Six Algerian Propolis Extracts: Ethyl Acetate Extracts Inhibit Myeloperoxidase Activity." Int. J. Mol. Sci. 15, no. 2: 2327-2345.

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