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Int. J. Mol. Sci. 2014, 15(2), 1927-1945; doi:10.3390/ijms15021927
Article

Elevated Th22 Cells Correlated with Th17 Cells in Peripheral Blood of Patients with Acute Myeloid Leukemia

1
, 1
, 2
, 3
, 1
, 4
, 1
, 1
, 1
 and 1,*
1 Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China 2 Department of Orthopedics, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250012, China 3 Department of Stomatology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China 4 Department of Oncology, Qilu Hospital, Shandong University, Jinan 250012, China
* Author to whom correspondence should be addressed.
Received: 20 December 2013 / Revised: 8 January 2014 / Accepted: 21 January 2014 / Published: 27 January 2014
(This article belongs to the Section Molecular Pathology)
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Abstract

Acute myeloid leukemia (AML) is a hematological tumor in which progress T helper (Th) subsets including Th22, Th17, and Th1 cells play a pivotal role. However, the role of T helper (Th) subsets in the immune pathogenesis of AML remains unclear. Here, we investigated frequencies of Th22, Th17, pure Th17, and Th1 cells in the peripheral blood (PB) of AML patients. We demonstrated that Th22, Th17, and pure Th17 in newly-diagnosed (ND) and non-complete remission (Non-CR) AML patients and plasma IL-22 in ND AML patients were significantly increased. Retinoid-related orphan receptor C (RORC) expression was significantly elevated in CR and Non-CR AML patients. However, Th1 in ND AML patients and IL-17 in ND, Non-CR or CR AML patients was significantly decreased compared with controls. Moreover, Th22 and IL-22 showed positive correlation with pure Th17, but Th22 showed negative correlation with Th1 in ND AML patients. RORC showed positive correlation with Th22 and approximately positive correlation with pure Th17 in Non-CR patients. PB blast cell showed positive correlation with Th22 and negative correlation with Th1 in ND AML patients. Our results indicate that Th22 and pure Th17 cells conjointly contribute to the pathogenesis of AML and might be promising novel clinical index for AML.
Keywords: acute myeloid leukemia; T helper 22; T helper 17; T helper 1; interleukin-22; interleukin-17 acute myeloid leukemia; T helper 22; T helper 17; T helper 1; interleukin-22; interleukin-17
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yu, S.; Liu, C.; Zhang, L.; Shan, B.; Tian, T.; Hu, Y.; Shao, L.; Sun, Y.; Ji, C.; Ma, D. Elevated Th22 Cells Correlated with Th17 Cells in Peripheral Blood of Patients with Acute Myeloid Leukemia. Int. J. Mol. Sci. 2014, 15, 1927-1945.

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