Next Article in Journal
Nickel Nanoparticles Exposure and Reproductive Toxicity in Healthy Adult Rats
Previous Article in Journal
Molecular Characterization of the BMP7 Gene and Its Potential Role in Shell Formation in Pinctada martensii
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(11), 21229-21252; doi:10.3390/ijms151121229

From Plasminogen to Plasmin: Role of Plasminogen Receptors in Human Cancer

Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
The German Center for Lung Research, 35392 Giessen, Germany
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 27 August 2014 / Revised: 4 November 2014 / Accepted: 12 November 2014 / Published: 17 November 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [1171 KB, uploaded 17 November 2014]   |  


Cell surface-associated proteolysis mediated by plasmin (PLA) is an essential feature of wound healing, angiogenesis and cell invasion, processes that are dysregulated in cancer development, progression and systemic spread. The generation of PLA, initiated by the binding of its precursor plasminogen (PLG) to the cell surface, is regulated by an array of activators, inhibitors and receptors. In this review, we will highlight the importance of the best-characterized components of the PLG/PLA cascade in the pathogenesis of cancer focusing on the role of the cell surface-PLG receptors (PLG-R). PLG-R overexpression has been associated with poor prognosis of cancer patients and resistance to chemotherapy. We will also discuss recent findings on the molecular mechanisms regulating cell surface expression and distribution of PLG-R. View Full-Text
Keywords: actin; annexin 2; cytokeratin-8; enolase-1; plasmin; plasminogen; plasminogen receptor actin; annexin 2; cytokeratin-8; enolase-1; plasmin; plasminogen; plasminogen receptor

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Didiasova, M.; Wujak, L.; Wygrecka, M.; Zakrzewicz, D. From Plasminogen to Plasmin: Role of Plasminogen Receptors in Human Cancer. Int. J. Mol. Sci. 2014, 15, 21229-21252.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top