Next Article in Journal
Post-Transcriptional Up-Regulation of PDGF-C by HuR in Advanced and Stressed Breast Cancer
Previous Article in Journal
Hunting the Needle in the Haystack: A Guide to Obtain Biologically Meaningful MicroRNA Targets
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2014, 15(11), 20290-20305; doi:10.3390/ijms151120290

Nrf2 and Redox Status in Prediabetic and Diabetic Patients

1
Faculty of Chemistry, Department of Biology, National Autonomous University of Mexico (UNAM), University City 04510 DF, Mexico
2
Faculty of Medicine, Department of Pharmacology, National Autonomous University of Mexico (UNAM), University City 04510 DF, Mexico
3
Research Department, Hospital Regional "Lic. Adolfo López Mateos", ISSSTE, Av. Universidad 1321, Florida 01030 DF, Mexico
*
Author to whom correspondence should be addressed.
Received: 22 October 2014 / Revised: 1 November 2014 / Accepted: 3 November 2014 / Published: 6 November 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [1015 KB, uploaded 6 November 2014]   |  

Abstract

The redox status associated with nuclear factor erythroid 2-related factor-2 (Nrf2) was evaluated in prediabetic and diabetic subjects. Total antioxidant status (TAS) in plasma and erythrocytes, glutathione (GSH) and malondialdehyde (MDA) content and activity of antioxidant enzymes were measured as redox status markers in 259 controls, 111 prediabetics and 186 diabetic type 2 subjects. Nrf2 was measured in nuclear extract fractions from peripheral blood mononuclear cells (PBMC). Nrf2 levels were lower in prediabetic and diabetic patients. TAS, GSH and activity of glutamate cysteine ligase were lower in diabetic subjects. An increase of MDA and superoxide dismutase activity was found in diabetic subjects. These results suggest that low levels of Nrf2 are involved in the development of oxidative stress and redox status disbalance in diabetic patients. View Full-Text
Keywords: Nrf2; prediabetes; diabetes; oxidative stress; glycated hemoglobin Nrf2; prediabetes; diabetes; oxidative stress; glycated hemoglobin
Figures

Figure 1a

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Jiménez-Osorio, A.S.; Picazo, A.; González-Reyes, S.; Barrera-Oviedo, D.; Rodríguez-Arellano, M.E.; Pedraza-Chaverri, J. Nrf2 and Redox Status in Prediabetic and Diabetic Patients. Int. J. Mol. Sci. 2014, 15, 20290-20305.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top