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Int. J. Mol. Sci. 2014, 15(11), 19760-19776; doi:10.3390/ijms151119760

Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity

1
Research Unit for Multi-Factorial Diseases, Obesity and Diabetes, Scientific Directorate, Bambino Gesù Children Hospital, Rome 00146, Italy
2
Department of Laboratory Medicine, Bambino Gesù Children Hospital, Rome 00146, Italy
3
Faculty of Health and Physical Activity Science, University (SEK), Santiago de Chile, Chile
*
Author to whom correspondence should be addressed.
Received: 8 July 2014 / Revised: 21 August 2014 / Accepted: 28 September 2014 / Published: 29 October 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

White adipose tissue (WAT) asset, in terms of cell number, fat storage capacity and endocrine function, is largely determined in early stages of life and is pivotal for shaping the WAT pro-inflammatory behavior. WAT derived adipokines have been shown to play a main role in several cardio-metabolic abnormalities of obesity. This review focuses on the most recently identified adipokines, namely adipocyte-fatty acid-binding protein, chemerin, fibroblast growth factor-21, lipocalin-2, omentin-1 and vaspin; their role in the pathogenesis of obesity and associated cardio-metabolic abnormalities; and on their adaptive response to body weight change. Evidence consistently suggests a pathogenic role for A-FABP, chemerin and FGF-21. Nevertheless, large population studies are needed to verify whether they can be useful to predict the risk of cardio-metabolic abnormalities in adulthood and/or monitor the clinical response to therapeutic interventions. View Full-Text
Keywords: adipose tissue; adipokines; cardiovascular disease; childhood obesity; inflammation; metabolic syndrome adipose tissue; adipokines; cardiovascular disease; childhood obesity; inflammation; metabolic syndrome
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Barraco, G.M.; Luciano, R.; Semeraro, M.; Prieto-Hontoria, P.L.; Manco, M. Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity. Int. J. Mol. Sci. 2014, 15, 19760-19776.

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