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Int. J. Mol. Sci. 2014, 15(11), 19330-19341; doi:10.3390/ijms151119330

Genetic Variations rs11892031 and rs401681 Are Associated with Bladder Cancer Risk in a Chinese Population

1
Department of Urology, the Second Hospital of Tianjin Medical University, Pingjiang Road 23, Hexi District, Tianjin 300211, China
2
Tianjin Key Laboratory of Urology, Tianjin Institute of Urology, the Second Hospital of Tianjin Medical University, Tianjin 300211, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 5 September 2014 / Revised: 13 October 2014 / Accepted: 15 October 2014 / Published: 24 October 2014
(This article belongs to the Collection Human Single Nucleotide Polymorphisms and Disease Diagnostics)
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Abstract

Genome-wide association studies (GWAS) have identified a number of genetic variants associated with risk of bladder cancer in populations of European descent. Here, we assessed association of two of these variants, rs11892031 (2q37.1 region) and rs401681 (5p15.33 region) in a Chinese case-control study, which included 367 bladder cancer cases and 420 controls. We found that the AC genotype of rs11892031 was associated with remarkably decreased risk of bladder cancer (adjusted odds ratio (OR), 0.27; 95% confidence interval (CI), 0.09–0.81; p = 0.019), compared with the AA genotype of rs11892031; and that CT/CC genotypes of rs401681 were associated with significantly increased risk of bladder cancer (adjusted OR, 1.79; 95% CI, 1.10–2.91; p = 0.02), compared with the TT genotype of rs401681. We further conducted stratification analysis to examine the correlation between single nucleotide polymorphism (SNP) rs11892031/rs401681 and tumor grade/stage. Results showed that heterogeneity in ORs of tumor categories was not significant for either rs11892031 or rs401681 (p > 0.05), indicating that the two SNPs seemingly do not associate with tumor grade and stage of bladder cancer in our study population. The present study suggests that the SNPs rs11892031 and rs401681 are associated with bladder cancer risk in a Chinese population. Future analyses will be conducted with more participants recruited in a case-control study. View Full-Text
Keywords: bladder cancer; genetic variations; polymorphism; genome-wide association studies bladder cancer; genetic variations; polymorphism; genome-wide association studies
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, Y.; Sun, Y.; Chen, T.; Hu, H.; Xie, W.; Qiao, Z.; Ding, N.; Xie, L.; Li, S.; Wang, W.; Xing, C.; Wang, Y.; Qie, Y.; Wu, C. Genetic Variations rs11892031 and rs401681 Are Associated with Bladder Cancer Risk in a Chinese Population. Int. J. Mol. Sci. 2014, 15, 19330-19341.

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