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Int. J. Mol. Sci. 2014, 15(11), 19342-19354; doi:10.3390/ijms151119342

Processed Aloe vera Gel Ameliorates Cyclophosphamide-Induced Immunotoxicity

1
College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea
2
Univera Inc., Seoul 133-120, Korea
3
College of Pharmacy, Korea University, Sejong 339-700, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 19 August 2014 / Revised: 28 September 2014 / Accepted: 21 October 2014 / Published: 24 October 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

The effects of processed Aloe vera gel (PAG) on cyclophosphamide (CP)-induced immunotoxicity were examined in mice. Intraperitoneal injection of CP significantly reduced the total number of lymphocytes and erythrocytes in the blood. Oral administration of PAG quickly restored CP-induced lymphopenia and erythropenia in a dose-dependent manner. The reversal of CP-induced hematotoxicity by PAG was mediated by the functional preservation of Peyer’s patch cells. Peyer’s patch cells isolated from CP-treated mice, which were administered PAG, produced higher levels of T helper 1 cytokines and colony-stimulating factors (CSF) in response to concanavalin A stimulation as compared with those isolated from CP-treated control mice. PAG-derived polysaccharides directly activated Peyer’s patch cells isolated from normal mice to produce cytokines including interleukin (IL)-6, IL-12, interferon-γ, granulocyte-CSF, and granulocyte-macrophage-CSF. The cytokines produced by polysaccharide-stimulated Peyer’s patch cells had potent proliferation-inducing activity on mouse bone marrow cells. In addition, oral administration of PAG restored IgA secretion in the intestine after CP treatment. These results indicated that PAG could be an effective immunomodulator and that it could prevent CP-induced immunotoxic side effects. View Full-Text
Keywords: processed Aloe vera gel; polysaccharide; cyclophosphamide; lymphopenia; erythropenia; Peyer’s patch; immunomodulation; IgA processed Aloe vera gel; polysaccharide; cyclophosphamide; lymphopenia; erythropenia; Peyer’s patch; immunomodulation; IgA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Im, S.-A.; Kim, K.-H.; Kim, H.-S.; Lee, K.-H.; Shin, E.; Do, S.-G.; Jo, T.H.; Park, Y.I.; Lee, C.-K. Processed Aloe vera Gel Ameliorates Cyclophosphamide-Induced Immunotoxicity. Int. J. Mol. Sci. 2014, 15, 19342-19354.

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