Dual Drug Release Electrospun Core-Shell Nanofibers with Tunable Dose in the Second Phase
Abstract
:1. Introduction
2. Results and Discussion
2.1. The Teflon-Coated Concentric Spinneret and the Modified Coaxial Electrospinning
2.2. Morphology and Structure of Nanofibers
2.3. Physical Status and Compatibility of Components
2.4. Dual Release Profiles with Tunable Dose in the Second Phase
3. Experimental Section
3.1. Materials
3.2. Modified Coaxial Electrospinning
3.3. Characterization
3.3.1. Morphology
3.3.2. Physical Status and Compatibility
3.3.3. In Vitro Dissolution Tests
4. Conclusions
Acknowledgments
Conflicts of Interest
References
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No. | Process | Drug con. (w/v) | Flow rate (mL/h) | Morphology c | Total drug content d | Diameter (nm) | ||
---|---|---|---|---|---|---|---|---|
Shell a | Core b | Shell | Core | |||||
F1 | Single | - | 3% | - | 1.0 | Linear | 11.11% | 570 ± 140 |
F2 | 5% | - | 1.0 | - | - | - | - | |
F3 | Coaxial | 5% | 3% | 0.3 | 1.0 | Linear | 13.64% | 930 ± 170 |
F4 | 5% | 6% | 0.3 | 1.0 | Linear | 20.83% | 910 ± 220 | |
F5 | 5% | 6% | 0.3 | 0.5 | Mixed | - | - |
Nanofiber No. | Release in the 1st phase (1 min) | Release after 24 h b | Release in the 2nd phase | ||
---|---|---|---|---|---|
Theoretical a | Experimental b | Theoretical a | Experimental b | ||
F1 | - | 10.7% (2.1) | 85.4% (17.1) | - | 74.7% (14.9) |
F3 | 33.3% (6.7) | 41.6% (8.3) | 92.7% (18.5) | 66.7% (13.3) | 51.1% (10.2) |
F4 | 20.0% (4.0) | 28.7% (5.7) | 91.4% (18.3) | 80.0% (16.0) | 62.7% (12.5) |
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Qian, W.; Yu, D.-G.; Li, Y.; Liao, Y.-Z.; Wang, X.; Wang, L. Dual Drug Release Electrospun Core-Shell Nanofibers with Tunable Dose in the Second Phase. Int. J. Mol. Sci. 2014, 15, 774-786. https://doi.org/10.3390/ijms15010774
Qian W, Yu D-G, Li Y, Liao Y-Z, Wang X, Wang L. Dual Drug Release Electrospun Core-Shell Nanofibers with Tunable Dose in the Second Phase. International Journal of Molecular Sciences. 2014; 15(1):774-786. https://doi.org/10.3390/ijms15010774
Chicago/Turabian StyleQian, Wei, Deng-Guang Yu, Ying Li, Yao-Zu Liao, Xia Wang, and Lu Wang. 2014. "Dual Drug Release Electrospun Core-Shell Nanofibers with Tunable Dose in the Second Phase" International Journal of Molecular Sciences 15, no. 1: 774-786. https://doi.org/10.3390/ijms15010774