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Int. J. Mol. Sci. 2014, 15(1), 774-786; doi:10.3390/ijms15010774
Article

Dual Drug Release Electrospun Core-Shell Nanofibers with Tunable Dose in the Second Phase

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Received: 19 November 2013 / Revised: 26 December 2013 / Accepted: 27 December 2013 / Published: 8 January 2014
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

This study reports a new type of drug-loaded core-shell nanofibers capable of providing dual controlled release with tunable dose in the second phase. The core-shell nanofibers were fabricated through a modified coaxial electrospinning using a Teflon-coated concentric spinneret. Poly(vinyl pyrrolidone) and ethyl cellulose were used as the shell and core polymer matrices respectively, and the content of active ingredient acetaminophen (APAP) in the core was programmed. The Teflon-coated concentric spinneret may facilitate the efficacious and stable preparation of core-shell nanofibers through the modified coaxial electrospinning, where the core fluids were electrospinnable and the shell fluid had no electrospinnability. The resultant nanofibers had linear morphologies and clear core-shell structures, as observed by the scanning and transmission electron microscopic images. APAP was amorphously distributed in the shell and core polymer matrices due to the favorite second-order interactions, as indicated by the X-ray diffraction and FTIR spectroscopic tests. The results from the in vitro dissolution tests demonstrated that the core-shell nanofibers were able to furnish the desired dual drug controlled-release profiles with a tunable drug release amount in the second phase. The modified coaxial electrospinning is a useful tool to generate nanostructures with a tailored components and compositions in their different parts, and thus to realize the desired functional performances.
Keywords: modified coaxial electrospinning; core-shell nanofibers; dual drug release; Teflon-coated spinneret; tunable dose modified coaxial electrospinning; core-shell nanofibers; dual drug release; Teflon-coated spinneret; tunable dose
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Qian, W.; Yu, D.-G.; Li, Y.; Liao, Y.-Z.; Wang, X.; Wang, L. Dual Drug Release Electrospun Core-Shell Nanofibers with Tunable Dose in the Second Phase. Int. J. Mol. Sci. 2014, 15, 774-786.

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