Int. J. Mol. Sci. 2014, 15(1), 1590-1605; doi:10.3390/ijms15011590
Article

Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)

1,* email, 1email, 2email, 2email, 1email, 3email and 3,* email
Received: 9 December 2013; in revised form: 3 January 2014 / Accepted: 6 January 2014 / Published: 22 January 2014
(This article belongs to the Special Issue Interaction between Nano-Structure Materials and Cells)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: One of the most challenging efforts in drug delivery is the targeting of the eye. The eye structure and barriers render this organ poorly permeable to drugs. Quite recently the entrance of nanoscience in ocular drug delivery has improved the penetration and half-life of drugs, especially in the anterior eye chamber, while targeting the posterior chamber is still an open issue. The retina and the retinal pigment epithelium/choroid tissues, located in the posterior eye chamber, are responsible for the majority of blindness both in childhood and adulthood. In the present study, we used magnetic nanoparticles (MNPs) as a nanotool for ocular drug delivery that is capable of specific localization in the retinal pigmented epithelium (RPE) layer. We demonstrate that, following intraocular injection in Xenopus embryos, MNPs localize specifically in RPE where they are retained for several days. The specificity of the localization did not depend on particle size and surface properties of the MNPs used in this work. Moreover, through similar experiments in zebrafish, we demonstrated that the targeting of RPE by the nanoparticles is not specific for the Xenopus species.
Keywords: magnetic nanoparticle (MNP); intraocular delivery; retinal pigmented epithelium (RPE); Xenopus laevis
PDF Full-text Download PDF Full-Text [1066 KB, uploaded 19 June 2014 05:25 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Giannaccini, M.; Giannini, M.; Calatayud, M.P.; Goya, G.F.; Cuschieri, A.; Dente, L.; Raffa, V. Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE). Int. J. Mol. Sci. 2014, 15, 1590-1605.

AMA Style

Giannaccini M, Giannini M, Calatayud MP, Goya GF, Cuschieri A, Dente L, Raffa V. Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE). International Journal of Molecular Sciences. 2014; 15(1):1590-1605.

Chicago/Turabian Style

Giannaccini, Martina; Giannini, Marianna; Calatayud, M. P.; Goya, Gerardo F.; Cuschieri, Alfred; Dente, Luciana; Raffa, Vittoria. 2014. "Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)." Int. J. Mol. Sci. 15, no. 1: 1590-1605.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert