Int. J. Mol. Sci. 2014, 15(1), 1499-1510; doi:10.3390/ijms15011499
Article

Genetic Deletion of Rheb1 in the Brain Reduces Food Intake and Causes Hypoglycemia with Altered Peripheral Metabolism

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Received: 16 November 2013; in revised form: 12 December 2013 / Accepted: 7 January 2014 / Published: 21 January 2014
(This article belongs to the Section Molecular Pathology)
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Abstract: Excessive food/energy intake is linked to obesity and metabolic disorders, such as diabetes. The hypothalamus in the brain plays a critical role in the control of food intake and peripheral metabolism. The signaling pathways in hypothalamic neurons that regulate food intake and peripheral metabolism need to be better understood for developing pharmacological interventions to manage eating behavior and obesity. Mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a master regulator of cellular metabolism in different cell types. Pharmacological manipulations of mTOR complex 1 (mTORC1) activity in hypothalamic neurons alter food intake and body weight. Our previous study identified Rheb1 (Ras homolog enriched in brain 1) as an essential activator of mTORC1 activity in the brain. Here we examine whether central Rheb1 regulates food intake and peripheral metabolism through mTORC1 signaling. We find that genetic deletion of Rheb1 in the brain causes a reduction in mTORC1 activity and impairs normal food intake. As a result, Rheb1 knockout mice exhibit hypoglycemia and increased lipid mobilization in adipose tissue and ketogenesis in the liver. Our work highlights the importance of central Rheb1 signaling in euglycemia and energy homeostasis in animals.
Keywords: Rheb1; genetic deletion; food intake; hypoglycemia; ketogenesis
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MDPI and ACS Style

Yang, W.; Jiang, W.; Luo, L.; Bu, J.; Pang, D.; Wei, J.; Du, C.; Xia, X.; Cui, Y.; Liu, S.; Mao, Q.; Chen, M. Genetic Deletion of Rheb1 in the Brain Reduces Food Intake and Causes Hypoglycemia with Altered Peripheral Metabolism. Int. J. Mol. Sci. 2014, 15, 1499-1510.

AMA Style

Yang W, Jiang W, Luo L, Bu J, Pang D, Wei J, Du C, Xia X, Cui Y, Liu S, Mao Q, Chen M. Genetic Deletion of Rheb1 in the Brain Reduces Food Intake and Causes Hypoglycemia with Altered Peripheral Metabolism. International Journal of Molecular Sciences. 2014; 15(1):1499-1510.

Chicago/Turabian Style

Yang, Wanchun; Jiang, Wanxiang; Luo, Liping; Bu, Jicheng; Pang, Dejiang; Wei, Jing; Du, Chongyangzi; Xia, Xiaoqiang; Cui, Yiyuan; Liu, Shuang; Mao, Qing; Chen, Mina. 2014. "Genetic Deletion of Rheb1 in the Brain Reduces Food Intake and Causes Hypoglycemia with Altered Peripheral Metabolism." Int. J. Mol. Sci. 15, no. 1: 1499-1510.


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