Next Article in Journal
Secondary Plant Products Causing Photosensitization in Grazing Herbivores: Their Structure, Activity and Regulation
Previous Article in Journal
Circulating MicroRNAs as Biomarkers of Acute Stroke
Article Menu

Export Article

Open AccessCommunication
Int. J. Mol. Sci. 2014, 15(1), 1433-1440; doi:10.3390/ijms15011433

Low Prostate Concentration of Lycopene Is Associated with Development of Prostate Cancer in Patients with High-Grade Prostatic Intraepithelial Neoplasia

Division of Urology, Department of Surgery, Sant'Andrea Hospital, Rome 00189, Italy
Urology Department, Fabia Mater Hospital, Rome 00171, Italy
Advanced Molecular Diagnostics Unit, Sant'Andrea Hospital, Rome 00189, Italy
Department of Neurosciences, Mental Health and Sensory Organs–Sapienza University of Rome, Piazzale Aldo Moro, 5, Roma 00185, Italy
Department of Clinical and Molecular Medicine, Sapienza University of Rome, Piazzale Aldo Moro, 5, Roma 00185, Italy
Center for Infectious Diseases, Boston Medical Center, Boston, MA 02118, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 10 October 2013 / Revised: 11 December 2013 / Accepted: 8 January 2014 / Published: 21 January 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [268 KB, uploaded 19 June 2014]   |  


Prostate cancer (PC) is a frequent male malignancy and represents the second most diagnosed cancer in men. Since pre-cancerous lesions, i.e., the high-grade prostatic intraepithelial neoplasia (HGPIN), can be detected years before progression to PC, early diagnosis and chemoprevention are targeted strategies to reduce PC rates. Animal studies have shown that lycopene, a carotenoid contained in tomatoes, is a promising candidate for the chemoprevention of PC. However, its efficacy in humans remains controversial. The present study aimed to investigate the relevance of plasma and prostate concentration of lycopene after a lycopene-enriched diet in patients diagnosed with HGPIN. Thirty-two patients diagnosed with HGPIN were administered a lycopene-enriched diet (20–25 mg/day of lycopene; through 30 g/day of triple concentrated tomato paste) for 6 months. A 6-month follow-up prostate biopsy assessed progression to PC. Patients were classified into three groups according to the histopathological features of the 6-month follow-up biopsy results: prostatitis; HGPIN and PC. PSA and plasma lycopene levels were measured before and after the dietary lycopene supplementation. Prostatic lycopene concentration was only assessed after the supplementation diet. Only prostatic lycopene concentration showed significant differences between the three groups (p = 0.03). Prostatic lycopene concentration below a 1 ng/mg threshold was associated with PC at 6-month follow-up biopsy (p = 0.003). We observed no overall benefits from a 6-month lycopene supplementation, as the rate of HGPIN progression to PC in our population (9/32, 28%) was similar to rates reported in the literature. Baseline PSA levels also showed no significant changes after a lycopene-enriched diet. Our findings point to prostatic lycopene concentration as a promising biomarker of PC. Further prospective longitudinal studies are needed to assess the prognostic role of prostatic lycopene in PC. View Full-Text
Keywords: lycopene; prostate cancer; prostatic lycopene; HGPIN lycopene; prostate cancer; prostatic lycopene; HGPIN

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Mariani, S.; Lionetto, L.; Cavallari, M.; Tubaro, A.; Rasio, D.; De Nunzio, C.; Hong, G.M.; Borro, M.; Simmaco, M. Low Prostate Concentration of Lycopene Is Associated with Development of Prostate Cancer in Patients with High-Grade Prostatic Intraepithelial Neoplasia. Int. J. Mol. Sci. 2014, 15, 1433-1440.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top