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The Clinical Utilization of Circulating Cell Free DNA (CCFDNA) in Blood of Cancer Patients
Division of Cancer Research and Training, Department of Internal Medicine, Charles Drew University of Medicine and Science, 1720 East 120th Street, Los Angeles, CA 90059, USA
Laboratory Diagnostic Medicine, Faculty of Pharmacy, Mazzeh (17th April Street), Damascus University, Damascus, Syria
David Geffen School of Medicine at UCLA, UCLA's Jonsson Comprehensive Cancer Center, 8-684 Factor Building, Box 951781, Los Angeles, CA 90095-1781, USA
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 4 June 2013; in revised form: 26 August 2013 / Accepted: 30 August 2013 / Published: 13 September 2013
Abstract: Qualitative and quantitative testing of circulating cell free DNA (CCFDNA) can be applied for the management of malignant and benign neoplasms. Detecting circulating DNA in cancer patients may help develop a DNA profile for early stage diagnosis in malignancies. The technical issues of obtaining, using, and analyzing CCFDNA from blood will be discussed.
Keywords: circulating cell free DNA; neoplasms; early diagnosis; follow up on cancer treatment; prognosis
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Elshimali, Y.I.; Khaddour, H.; Sarkissyan, M.; Wu, Y.; Vadgama, J.V. The Clinical Utilization of Circulating Cell Free DNA (CCFDNA) in Blood of Cancer Patients. Int. J. Mol. Sci. 2013, 14, 18925-18958.
Elshimali YI, Khaddour H, Sarkissyan M, Wu Y, Vadgama JV. The Clinical Utilization of Circulating Cell Free DNA (CCFDNA) in Blood of Cancer Patients. International Journal of Molecular Sciences. 2013; 14(9):18925-18958.
Elshimali, Yahya I.; Khaddour, Husseina; Sarkissyan, Marianna; Wu, Yanyuan; Vadgama, Jaydutt V. 2013. "The Clinical Utilization of Circulating Cell Free DNA (CCFDNA) in Blood of Cancer Patients." Int. J. Mol. Sci. 14, no. 9: 18925-18958.