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Magnetic Nanosystem for Cancer Therapy Using Oncocalyxone A, an Antitomour Secondary Metabolite Isolated from a Brazilian Plant
Advanced Materials Chemistry Group (GQMAT), Analytical and Physical-Chemistry Department, Federal University of Ceará (UFC), Campus do Pici 12100, CEP 60451-970 Fortaleza-CE, Brazil
Products Laboratory and Process Technology (LPT), Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza-CE 12100, Brazil
Physical Department, Santiago University of Chile (USACH), Av. Ecuador 3493, Santiago 9160000, Chile
Department of Engineering for Innovation, University of Salento, Via Arnesano, Lecce 73100, Italy
Laboratory of Polymers and Materials Innovation (LPIM), Department of Organic and Inorganic Chemistry, Federal University of Ceará, Ceará 12100, Brazil
Department of Pharmacy, Federal University of Ceará (UFC), Fortaleza-Ceará 12100, Brazil
National Nanotechnology Laboratory, Nanoscience Institute-CNR Via Arnesano, Lecce 73100, Italy
* Author to whom correspondence should be addressed.
Received: 13 April 2013; in revised form: 23 June 2013 / Accepted: 13 July 2013 / Published: 5 September 2013
Abstract: This paper describes the investigation and development of a novel magnetic drug delivery nanosystem (labeled as MO-20) for cancer therapy. The drug employed was oncocalyxone A (onco A), which was isolated from Auxemma oncocalyx, an endemic Brazilian plant. It has a series of pharmacological properties: antioxidant, cytotoxic, analgesic, anti-inflammatory, antitumor and antiplatelet. Onco A was associated with magnetite nanoparticles in order to obtain magnetic properties. The components of MO-20 were characterized by XRD, FTIR, TGA, TEM and Magnetization curves. The MO-20 presented a size of about 30 nm and globular morphology. In addition, drug releasing experiments were performed, where it was observed the presence of the anomalous transport. The results found in this work showed the potential of onco A for future applications of the MO-20 as a new magnetic drug release nanosystem for cancer treatment.
Keywords: drug delivery; cancer therapy; magnetic nanoparticles; oncocalyxone A
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Barreto, A.C.H.; Santiago, V.R.; Freire, R.M.; Mazzetto, S.E.; Denardin, J.C.; Mele, G.; Cavalcante, I.M.; Ribeiro, M.E.N.P.; Ricardo, N.M.P.S.; Gonçalves, T.; Carbone, L.; Lemos, T.L.G.; Pessoa, O.D.L.; Fechine, P.B.A. Magnetic Nanosystem for Cancer Therapy Using Oncocalyxone A, an Antitomour Secondary Metabolite Isolated from a Brazilian Plant. Int. J. Mol. Sci. 2013, 14, 18269-18283.
Barreto ACH, Santiago VR, Freire RM, Mazzetto SE, Denardin JC, Mele G, Cavalcante IM, Ribeiro MENP, Ricardo NMPS, Gonçalves T, Carbone L, Lemos TLG, Pessoa ODL, Fechine PBA. Magnetic Nanosystem for Cancer Therapy Using Oncocalyxone A, an Antitomour Secondary Metabolite Isolated from a Brazilian Plant. International Journal of Molecular Sciences. 2013; 14(9):18269-18283.
Barreto, Antônio C.H.; Santiago, Vivian R.; Freire, Rafael M.; Mazzetto, Selma E.; Denardin, Juliano C.; Mele, Giuseppe; Cavalcante, Igor M.; Ribeiro, Maria E.N.P.; Ricardo, Nágila M.P.S.; Gonçalves, Tamara; Carbone, Luigi; Lemos, Telma L.G.; Pessoa, Otília D.L.; Fechine, Pierre B.A. 2013. "Magnetic Nanosystem for Cancer Therapy Using Oncocalyxone A, an Antitomour Secondary Metabolite Isolated from a Brazilian Plant." Int. J. Mol. Sci. 14, no. 9: 18269-18283.