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Int. J. Mol. Sci. 2013, 14(9), 18269-18283; doi:10.3390/ijms140918269
Article

Magnetic Nanosystem for Cancer Therapy Using Oncocalyxone A, an Antitomour Secondary Metabolite Isolated from a Brazilian Plant

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1 Advanced Materials Chemistry Group (GQMAT), Analytical and Physical-Chemistry Department, Federal University of Ceará (UFC), Campus do Pici 12100, CEP 60451-970 Fortaleza-CE, Brazil 2 Products Laboratory and Process Technology (LPT), Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza-CE 12100, Brazil 3 Physical Department, Santiago University of Chile (USACH), Av. Ecuador 3493, Santiago 9160000, Chile 4 Department of Engineering for Innovation, University of Salento, Via Arnesano, Lecce 73100, Italy 5 Laboratory of Polymers and Materials Innovation (LPIM), Department of Organic and Inorganic Chemistry, Federal University of Ceará, Ceará 12100, Brazil 6 Department of Pharmacy, Federal University of Ceará (UFC), Fortaleza-Ceará 12100, Brazil 7 National Nanotechnology Laboratory, Nanoscience Institute-CNR Via Arnesano, Lecce 73100, Italy
* Author to whom correspondence should be addressed.
Received: 13 April 2013 / Revised: 23 June 2013 / Accepted: 13 July 2013 / Published: 5 September 2013
(This article belongs to the Special Issue Magnetic Nanoparticles 2013)
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Abstract

This paper describes the investigation and development of a novel magnetic drug delivery nanosystem (labeled as MO-20) for cancer therapy. The drug employed was oncocalyxone A (onco A), which was isolated from Auxemma oncocalyx, an endemic Brazilian plant. It has a series of pharmacological properties: antioxidant, cytotoxic, analgesic, anti-inflammatory, antitumor and antiplatelet. Onco A was associated with magnetite nanoparticles in order to obtain magnetic properties. The components of MO-20 were characterized by XRD, FTIR, TGA, TEM and Magnetization curves. The MO-20 presented a size of about 30 nm and globular morphology. In addition, drug releasing experiments were performed, where it was observed the presence of the anomalous transport. The results found in this work showed the potential of onco A for future applications of the MO-20 as a new magnetic drug release nanosystem for cancer treatment.
Keywords: drug delivery; cancer therapy; magnetic nanoparticles; oncocalyxone A drug delivery; cancer therapy; magnetic nanoparticles; oncocalyxone A
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Barreto, A.C.H.; Santiago, V.R.; Freire, R.M.; Mazzetto, S.E.; Denardin, J.C.; Mele, G.; Cavalcante, I.M.; Ribeiro, M.E.N.P.; Ricardo, N.M.P.S.; Gonçalves, T.; Carbone, L.; Lemos, T.L.G.; Pessoa, O.D.L.; Fechine, P.B.A. Magnetic Nanosystem for Cancer Therapy Using Oncocalyxone A, an Antitomour Secondary Metabolite Isolated from a Brazilian Plant. Int. J. Mol. Sci. 2013, 14, 18269-18283.

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