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Int. J. Mol. Sci. 2013, 14(9), 18269-18283; doi:10.3390/ijms140918269
Article

Magnetic Nanosystem for Cancer Therapy Using Oncocalyxone A, an Antitomour Secondary Metabolite Isolated from a Brazilian Plant

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Received: 13 April 2013; in revised form: 23 June 2013 / Accepted: 13 July 2013 / Published: 5 September 2013
(This article belongs to the Special Issue Magnetic Nanoparticles 2013)
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Abstract: This paper describes the investigation and development of a novel magnetic drug delivery nanosystem (labeled as MO-20) for cancer therapy. The drug employed was oncocalyxone A (onco A), which was isolated from Auxemma oncocalyx, an endemic Brazilian plant. It has a series of pharmacological properties: antioxidant, cytotoxic, analgesic, anti-inflammatory, antitumor and antiplatelet. Onco A was associated with magnetite nanoparticles in order to obtain magnetic properties. The components of MO-20 were characterized by XRD, FTIR, TGA, TEM and Magnetization curves. The MO-20 presented a size of about 30 nm and globular morphology. In addition, drug releasing experiments were performed, where it was observed the presence of the anomalous transport. The results found in this work showed the potential of onco A for future applications of the MO-20 as a new magnetic drug release nanosystem for cancer treatment.
Keywords: drug delivery; cancer therapy; magnetic nanoparticles; oncocalyxone A drug delivery; cancer therapy; magnetic nanoparticles; oncocalyxone A
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Barreto, A.C.H.; Santiago, V.R.; Freire, R.M.; Mazzetto, S.E.; Denardin, J.C.; Mele, G.; Cavalcante, I.M.; Ribeiro, M.E.N.P.; Ricardo, N.M.P.S.; Gonçalves, T.; Carbone, L.; Lemos, T.L.G.; Pessoa, O.D.L.; Fechine, P.B.A. Magnetic Nanosystem for Cancer Therapy Using Oncocalyxone A, an Antitomour Secondary Metabolite Isolated from a Brazilian Plant. Int. J. Mol. Sci. 2013, 14, 18269-18283.

AMA Style

Barreto ACH, Santiago VR, Freire RM, Mazzetto SE, Denardin JC, Mele G, Cavalcante IM, Ribeiro MENP, Ricardo NMPS, Gonçalves T, Carbone L, Lemos TLG, Pessoa ODL, Fechine PBA. Magnetic Nanosystem for Cancer Therapy Using Oncocalyxone A, an Antitomour Secondary Metabolite Isolated from a Brazilian Plant. International Journal of Molecular Sciences. 2013; 14(9):18269-18283.

Chicago/Turabian Style

Barreto, Antônio C.H.; Santiago, Vivian R.; Freire, Rafael M.; Mazzetto, Selma E.; Denardin, Juliano C.; Mele, Giuseppe; Cavalcante, Igor M.; Ribeiro, Maria E.N.P.; Ricardo, Nágila M.P.S.; Gonçalves, Tamara; Carbone, Luigi; Lemos, Telma L.G.; Pessoa, Otília D.L.; Fechine, Pierre B.A. 2013. "Magnetic Nanosystem for Cancer Therapy Using Oncocalyxone A, an Antitomour Secondary Metabolite Isolated from a Brazilian Plant." Int. J. Mol. Sci. 14, no. 9: 18269-18283.



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