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Int. J. Mol. Sci. 2013, 14(9), 18110-18123; doi:10.3390/ijms140918110
Article

Biohybrid Nanostructured Iron Oxide Nanoparticles and Satureja hortensis to Prevent Fungal Biofilm Development

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Received: 17 June 2013; in revised form: 5 August 2013 / Accepted: 23 August 2013 / Published: 4 September 2013
(This article belongs to the Special Issue Magnetic Nanoparticles 2013)
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Abstract: Cutaneous wounds are often superinfected during the healing process and this leads to prolonged convalescence and discomfort. Usage of suitable wound dressings is very important for an appropriate wound care leading to a correct healing. The aim of this study was to demonstrate the influence of a nano-coated wound dressing (WD) on Candida albicans colonization rate and biofilm formation. The modified WD was achieved by submerging the dressing pieces into a nanofluid composed of functionalized magnetite nanoparticles and Satureja hortensis (SO) essential oil (EO). Chemical composition of the EO was established by GC-MS. The fabricated nanostructure was characterized by X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), Differential Thermal Analysis (DTA) and Fourier Transform-Infrared Spectroscopy (FT-IR). The analysis of the colonized surfaces using (Scanning Electron Microscopy) SEM revealed that C. albicans adherence and subsequent biofilm development are strongly inhibited on the surface of wound dressing fibers coated with the obtained nanofluid, comparing with regular uncoated materials. The results were also confirmed by the assay of the viable fungal cells embedded in the biofilm. Our data demonstrate that the obtained phytonanocoating improve the resistance of wound dressing surface to C. albicans colonization, which is often an etiological cause of local infections, impairing the appropriate wound healing.
Keywords: nano-modified wound dressing; Satureja hortensis essential oil; fungal biofilm; Candida albicans; magnetite nanoparticles; iron oxide nano-modified wound dressing; Satureja hortensis essential oil; fungal biofilm; Candida albicans; magnetite nanoparticles; iron oxide
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Anghel, I.; Grumezescu, A.M.; Holban, A.M.; Ficai, A.; Anghel, A.G.; Chifiriuc, M.C. Biohybrid Nanostructured Iron Oxide Nanoparticles and Satureja hortensis to Prevent Fungal Biofilm Development. Int. J. Mol. Sci. 2013, 14, 18110-18123.

AMA Style

Anghel I, Grumezescu AM, Holban AM, Ficai A, Anghel AG, Chifiriuc MC. Biohybrid Nanostructured Iron Oxide Nanoparticles and Satureja hortensis to Prevent Fungal Biofilm Development. International Journal of Molecular Sciences. 2013; 14(9):18110-18123.

Chicago/Turabian Style

Anghel, Ion; Grumezescu, Alexandru M.; Holban, Alina M.; Ficai, Anton; Anghel, Alina G.; Chifiriuc, Mariana C. 2013. "Biohybrid Nanostructured Iron Oxide Nanoparticles and Satureja hortensis to Prevent Fungal Biofilm Development." Int. J. Mol. Sci. 14, no. 9: 18110-18123.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert