Next Article in Journal
Nanoconfinement-Induced Structures in Chiral Liquid Crystals
Next Article in Special Issue
Role of cMET in the Development and Progression of Colorectal Cancer
Previous Article in Journal
Renal Dopamine Receptors, Oxidative Stress, and Hypertension
Previous Article in Special Issue
Potential Targets for Colorectal Cancer Prevention
Int. J. Mol. Sci. 2013, 14(9), 17573-17583; doi:10.3390/ijms140917573
Review

Prevention of Carcinogenesis and Development of Gastric and Colon Cancers by 2-Aminophenoxazine-3-one (Phx-3): Direct and Indirect Anti-Cancer Activity of Phx-3

1,* , 1
 and 2
Received: 8 July 2013; in revised form: 20 August 2013 / Accepted: 21 August 2013 / Published: 28 August 2013
(This article belongs to the Special Issue Pathogenesis and Prevention of Colorectal Cancer)
View Full-Text   |   Download PDF [198 KB, uploaded 19 June 2014]   |   Browse Figures
Abstract: 2-Aminophenoxazine-3-one (Phx-3), an oxidative phenoxazine, exerts strong anticancer effects on various cancer cell lines originating from different organs, in vitro. This article reviews new aspects for the prevention of carcinogenesis and development of gastric and colon cancers by Phx-3, based on the strong anticancer effects of Phx-3 on gastric and colon cancer cell lines (direct anticancer effects of Phx-3 for preventing development of cancer), the bacteriocidal effects of Phx-3 against Helicobacter pylori associated with carcinogenesis of gastric cancer (indirect anticancer effects for preventing carcinogenesis of gastric cancer), and the proapoptotic activity of Phx-3 against human neutrophils involved in the incidence of ulcerative colitis associated with a high colon cancer risk (indirect anticancer effects for preventing carcinogenesis of colon cancer).
Keywords: Phx-3; gastric and colon cancers; apoptosis; neutrophils Phx-3; gastric and colon cancers; apoptosis; neutrophils
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Tomoda, A.; Miyazawa, K.; Tabuchi, T. Prevention of Carcinogenesis and Development of Gastric and Colon Cancers by 2-Aminophenoxazine-3-one (Phx-3): Direct and Indirect Anti-Cancer Activity of Phx-3. Int. J. Mol. Sci. 2013, 14, 17573-17583.

AMA Style

Tomoda A, Miyazawa K, Tabuchi T. Prevention of Carcinogenesis and Development of Gastric and Colon Cancers by 2-Aminophenoxazine-3-one (Phx-3): Direct and Indirect Anti-Cancer Activity of Phx-3. International Journal of Molecular Sciences. 2013; 14(9):17573-17583.

Chicago/Turabian Style

Tomoda, Akio; Miyazawa, Keisuke; Tabuchi, Takafumi. 2013. "Prevention of Carcinogenesis and Development of Gastric and Colon Cancers by 2-Aminophenoxazine-3-one (Phx-3): Direct and Indirect Anti-Cancer Activity of Phx-3." Int. J. Mol. Sci. 14, no. 9: 17573-17583.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert