Next Article in Journal
Functional and Molecular Changes of the Bladder in Rats with Crushing Injury of Nerve Bundles from Major Pelvic Ganglion to the Bladder: Role of RhoA/Rho Kinase Pathway
Next Article in Special Issue
Spin Polarization and Quantum Spins in Au Nanoparticles
Previous Article in Journal
Quorum Quenching Enzymes and Their Application in Degrading Signal Molecules to Block Quorum Sensing-Dependent Infection
Previous Article in Special Issue
Tuning the Magnetic Properties of Nanoparticles
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2013, 14(9), 17501-17510; doi:10.3390/ijms140917501

Materials Characterization of Feraheme/Ferumoxytol and Preliminary Evaluation of Its Potential for Magnetic Fluid Hyperthermia

1
Department of Materials Science & Engineering, University of Florida, Gainesville, FL 32611-6400, USA
2
Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611-6131, USA
3
Institute for Cell Engineering and Regenerative Medicine, University of Florida, Gainesville, FL 32611-6131, USA
*
Author to whom correspondence should be addressed.
Received: 26 June 2013 / Revised: 5 August 2013 / Accepted: 21 August 2013 / Published: 26 August 2013
(This article belongs to the Special Issue Magnetic Nanoparticles 2013)
View Full-Text   |   Download PDF [631 KB, uploaded 19 June 2014]   |  

Abstract

Feraheme, is a recently FDA-cleared superparamagnetic iron oxide nanoparticle (SPION)-based MRI contrast agent that is also employed in the treatment of iron deficiency anemia. Feraheme nanoparticles have a hydrodynamic diameter of 30 nm and consist of iron oxide crystallites complexed with a low molecular weight, semi-synthetic carbohydrate. These features are attractive for other potential biomedical applications such as magnetic fluid hyperthermia (MFH), since the carboxylated polymer coating affords functionalization of the particle surface and the size allows for accumulation in highly vascularized tumors via the enhanced permeability and retention effect. This work presents morphological and magnetic characterization of Feraheme by transmission electron microscopy (TEM), Energy dispersive X-ray spectroscopy (EDX), and superconducting quantum interference device (SQUID) magnetometry. Additionally, the results of an initial evaluation of the suitability of Feraheme for MFH applications are described, and the data indicate the particles possess promising properties for this application. View Full-Text
Keywords: Feraheme; magnetic fluid hyperthermia; magnetic nanoparticles; MRI contrast Feraheme; magnetic fluid hyperthermia; magnetic nanoparticles; MRI contrast
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bullivant, J.P.; Zhao, S.; Willenberg, B.J.; Kozissnik, B.; Batich, C.D.; Dobson, J. Materials Characterization of Feraheme/Ferumoxytol and Preliminary Evaluation of Its Potential for Magnetic Fluid Hyperthermia. Int. J. Mol. Sci. 2013, 14, 17501-17510.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top