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Int. J. Mol. Sci. 2013, 14(7), 14475-14503; doi:10.3390/ijms140714475

Membrane Trafficking of Death Receptors: Implications on Signalling

Institute for Clinical Microbiology and Hygiene, University of Regensburg, Franz-Josef-Strauss-Allee 11, Regensburg 93053, Germany
* Author to whom correspondence should be addressed.
Received: 9 May 2013 / Revised: 19 June 2013 / Accepted: 27 June 2013 / Published: 11 July 2013
(This article belongs to the Special Issue Regulation of Membrane Trafficking and Its Potential Implications)
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Death receptors were initially recognised as potent inducers of apoptotic cell death and soon ambitious attempts were made to exploit selective ignition of controlled cellular suicide as therapeutic strategy in malignant diseases. However, the complexity of death receptor signalling has increased substantially during recent years. Beyond activation of the apoptotic cascade, involvement in a variety of cellular processes including inflammation, proliferation and immune response was recognised. Mechanistically, these findings raised the question how multipurpose receptors can ensure selective activation of a particular pathway. A growing body of evidence points to an elegant spatiotemporal regulation of composition and assembly of the receptor-associated signalling complex. Upon ligand binding, receptor recruitment in specialized membrane compartments, formation of receptor-ligand clusters and internalisation processes constitute key regulatory elements. In this review, we will summarise the current concepts of death receptor trafficking and its implications on receptor-associated signalling events.
Keywords: death receptor; apoptosis; endocytosis; membrane trafficking; receptor internalisation death receptor; apoptosis; endocytosis; membrane trafficking; receptor internalisation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Schneider-Brachert, W.; Heigl, U.; Ehrenschwender, M. Membrane Trafficking of Death Receptors: Implications on Signalling. Int. J. Mol. Sci. 2013, 14, 14475-14503.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert