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Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery
Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, Brno CZ-613 00, Czech Republic
Central European Institute of Technology, Brno University of Technology, Technicka 3058/10, Brno CZ-616 00, Czech Republic
Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, Prague 2 CZ-128 40, Czech Republic
Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine and University Hospital Motol, Charles University, V Uvalu 84, Prague 5 CZ-150 06, Czech Republic
* Author to whom correspondence should be addressed.
Received: 19 April 2013; in revised form: 18 May 2013 / Accepted: 23 May 2013 / Published: 27 June 2013
Abstract: Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation with magnetic particles was investigated by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). The quantification of encapsulated doxorubicin was performed by fluorescence spectroscopy and compared to CE-LIF. Moreover, the significant enhancement of the doxorubicin signal was observed by addition of methanol into the sample solution.
Keywords: cancer; nanomedicine; magnetic particles; doxorubicin; nanoparticles
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Blazkova, I.; Nguyen, H.V.; Dostalova, S.; Kopel, P.; Stanisavljevic, M.; Vaculovicova, M.; Stiborova, M.; Eckschlager, T.; Kizek, R.; Adam, V. Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery. Int. J. Mol. Sci. 2013, 14, 13391-13402.
Blazkova I, Nguyen HV, Dostalova S, Kopel P, Stanisavljevic M, Vaculovicova M, Stiborova M, Eckschlager T, Kizek R, Adam V. Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery. International Journal of Molecular Sciences. 2013; 14(7):13391-13402.
Blazkova, Iva; Nguyen, Hoai V.; Dostalova, Simona; Kopel, Pavel; Stanisavljevic, Maja; Vaculovicova, Marketa; Stiborova, Marie; Eckschlager, Tomas; Kizek, Rene; Adam, Vojtech. 2013. "Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery." Int. J. Mol. Sci. 14, no. 7: 13391-13402.