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Int. J. Mol. Sci. 2013, 14(7), 13329-13345; doi:10.3390/ijms140713329
Article

Involvement of Intercellular Adhesion Molecule-1 Up-Regulation in Bradykinin Promotes Cell Motility in Human Prostate Cancers

1
, 2,3
 and 1,4,5,*
Received: 10 May 2013; in revised form: 4 June 2013 / Accepted: 5 June 2013 / Published: 26 June 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: Prostate cancer is the most commonly diagnosed malignancy in men and shows a predilection for metastasis to distant organs. Bradykinin (BK) is an inflammatory mediator and has recently been shown to mediate tumor growth and metastasis. The adhesion molecule intercellular adhesion molecule-1 (ICAM-1) plays a critical role during tumor metastasis. The aim of this study was to examine whether BK promotes prostate cancer cell migration via ICAM-1 expression. The motility of cancer cells was increased following BK treatment. Stimulation of prostate cancer cells with BK induced mRNA and protein expression of ICAM-1. Transfection of cells with ICAM-1 small interfering RNA reduced BK-increased cell migration. Pretreatment of prostate cancer cells with B2 receptor, phosphatidylinositol 3-kinase (PI3K), Akt, and activator protein 1 (AP-1) inhibitors or mutants abolished BK-promoted migration and ICAM-1 expression. In addition, treatment with a B2 receptor, PI3K, or Akt inhibitor also reduced BK-mediated AP-1 activation. Our results indicate that BK enhances the migration of prostate cancer cells by increasing ICAM-1 expression through a signal transduction pathway that involves the B2 receptor, PI3K, Akt, and AP-1. Thus, BK represents a promising new target for treating prostate cancer metastasis.
Keywords: bradykinin; migration; ICAM-1; prostate cancer bradykinin; migration; ICAM-1; prostate cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Yu, H.-S.; Lin, T.-H.; Tang, C.-H. Involvement of Intercellular Adhesion Molecule-1 Up-Regulation in Bradykinin Promotes Cell Motility in Human Prostate Cancers. Int. J. Mol. Sci. 2013, 14, 13329-13345.

AMA Style

Yu H-S, Lin T-H, Tang C-H. Involvement of Intercellular Adhesion Molecule-1 Up-Regulation in Bradykinin Promotes Cell Motility in Human Prostate Cancers. International Journal of Molecular Sciences. 2013; 14(7):13329-13345.

Chicago/Turabian Style

Yu, Hsin-Shan; Lin, Tien-Huang; Tang, Chih-Hsin. 2013. "Involvement of Intercellular Adhesion Molecule-1 Up-Regulation in Bradykinin Promotes Cell Motility in Human Prostate Cancers." Int. J. Mol. Sci. 14, no. 7: 13329-13345.


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