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Int. J. Mol. Sci. 2013, 14(7), 13005-13021; doi:10.3390/ijms140713005
Article

Anti-Tumor Effects of Mfn2 in Gastric Cancer

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Received: 26 March 2013 / Revised: 19 May 2013 / Accepted: 7 June 2013 / Published: 24 June 2013
(This article belongs to the Section Molecular Pathology)
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Abstract

Mitofusin-2 (Mfn2) is a mitochondrial outer membrane protein involved in mitochondrial fusion. Its mutation can cause Charcot-Marie-Tooth disease. Recent studies of Mfn2 in cancer research have not included gastric cancer. We confirmed that Mfn2 expression was lower in tumor tissue than in normal gastric mucosal tissue and that it was negatively correlated with tumor size, indicating an anti-tumor role for Mfn2. In vitro experiments showed that Mfn2 overexpression suppressed gastric cancer cell proliferation and colony formation, weakened the invasion and migratory ability of cancer cells by downregulating MMP-2 and MMP-9, halted the cell cycle and induced apoptosis. Western blotting indicated the likely involvement of P21 and PI3K/Akt signaling. Therefore, Mfn2 is a potential anti-tumor gene and a potential therapeutic target for treating gastric cancer. The progress of gastric cancer may be delayed by controlling Mfn2 expression.
Keywords: gastric cancer; Mfn2; biomarker; anti-tumor gene gastric cancer; Mfn2; biomarker; anti-tumor gene
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, G.-E.; Jin, H.-L.; Lin, X.-K.; Chen, C.; Liu, X.-S.; Zhang, Q.; Yu, J.-R. Anti-Tumor Effects of Mfn2 in Gastric Cancer. Int. J. Mol. Sci. 2013, 14, 13005-13021.

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