Int. J. Mol. Sci. 2013, 14(6), 12593-12606; doi:10.3390/ijms140612593
Article

Effect of Dietary Cholesterol and Cholesterol Oxides on Blood Cholesterol, Lipids, and the Development of Atherosclerosis in Rabbits

1 Department of Bioresources and Food Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701, Korea 2 Food Science and Technology Program, Department of Agriculture, Food, and Resource Science, University Maryland Eastern Shore, Princess Anne, MD 21853, USA 3 Department of Animal Science and Technology, Sunchon National University, Sunchon 540-742, Korea 4 Department of Food and Nutrition, University of Wisconsin-Stout, Menomonie, WI 54751, USA 5 Department of Animal Science, College of Agriculture, Iowa State University, Ames, IA 50011, USA 6 WCU Biomodulation, Department of Agricultural Biotechnology, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-921, Korea
* Author to whom correspondence should be addressed.
Received: 30 April 2013; in revised form: 31 May 2013 / Accepted: 5 June 2013 / Published: 17 June 2013
(This article belongs to the Section Molecular Toxicology)
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Abstract: Two studies were conducted to determine the effects of dietary cholesterol (CHO) and cholesterol oxides (COPs) on the development of atherosclerosis and the changes in fatty acid and blood characteristics in rabbits. In the first study, forty male New Zealand white rabbits were divided into 5 groups and fed commercial rabbit chow with no added CHO or COPs, 1 g CHO, 0.9 g CHO + 0.1 g COPs, 0.8 g CHO + 0.2 g COPs, or 0.5 g CHO + 0.5 g COPs per kg diet. In the second study, 24 male New Zealand White rabbits were divided into 3 groups and fed a diet containing 2 g CHO, 1.6 g CHO + 0.4 g COPs, or 1.2 g CHO + 0.8 g COPs per kg diet. All diets induced atherosclerotic lesions in the rabbits’ ascending thoracic aorta. The serum CHO and triglyceride levels (p < 0.05) increased significantly with the increased levels of CHO in the diets. Dietary CHO or COPs did not influence high-density lipoprotein CHO levels. The ratio of saturated fatty acid to unsaturated fatty acid increased as the level of dietary CHO and COPs increased.
Keywords: dietary cholesterol; cholesterol oxides; atherosclerosis; serum cholesterol; HDL

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MDPI and ACS Style

Hur, S.J.; Min, B.; Nam, K.C.; Lee, E.J.; Ahn, D.U. Effect of Dietary Cholesterol and Cholesterol Oxides on Blood Cholesterol, Lipids, and the Development of Atherosclerosis in Rabbits. Int. J. Mol. Sci. 2013, 14, 12593-12606.

AMA Style

Hur SJ, Min B, Nam KC, Lee EJ, Ahn DU. Effect of Dietary Cholesterol and Cholesterol Oxides on Blood Cholesterol, Lipids, and the Development of Atherosclerosis in Rabbits. International Journal of Molecular Sciences. 2013; 14(6):12593-12606.

Chicago/Turabian Style

Hur, Sun J.; Min, Byungrok; Nam, Ki C.; Lee, Eun J.; Ahn, Dong U. 2013. "Effect of Dietary Cholesterol and Cholesterol Oxides on Blood Cholesterol, Lipids, and the Development of Atherosclerosis in Rabbits." Int. J. Mol. Sci. 14, no. 6: 12593-12606.

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