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Anti-Inflammatory Components from the Root of Solanum erianthum
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Department of Cosmeceutics, China Medical University, Taichung 404, Taiwan
Taiwan Seed Improvement and Propagation Station, Council of Agriculture, Taichung 426, Taiwan
Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
Graduate Institute of Clinical Medical Science, China Medical University, Taichung 404, Taiwan
Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan
* Authors to whom correspondence should be addressed.
Received: 10 May 2013; in revised form: 7 June 2013 / Accepted: 13 June 2013 / Published: 14 June 2013
Abstract: Two new norsesquiterpenoids, solanerianones A and B (1–2), together with nine known compounds, including four sesquiterpenoids, (−)-solavetivone (3), (+)-anhydro-β-rotunol (4), solafuranone (5), lycifuranone A (6); one alkaloid, N-trans-feruloyltyramine (7); one fatty acid, palmitic acid (8); one phenylalkanoid, acetovanillone (9), and two steroids, β-sitosterol (10) and stigmasterol (11) were isolated from the n-hexane-soluble part of the roots of Solanum erianthum. Their structures were elucidated on the basis of physical and spectroscopic data analyses. The anti-inflammatory activity of these isolates was monitored by nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells. The cytotoxicity towards human lung squamous carcinoma (CH27), human hepatocellular carcinoma (Hep 3B), human oral squamous carcinoma (HSC-3) and human melanoma (M21) cell lines was also screened by using an MTT assay. Of the compounds tested, 3 exhibited the strongest NO inhibition with the average maximum inhibition (Emax) at 100 μM and median inhibitory concentration (IC50) values of 98.23% ± 0.08% and 65.54 ± 0.18 μM, respectively. None of compounds (1–9) was found to possess cytotoxic activity against human cancer cell lines at concentrations up to 30 μM.
Keywords: Solanum erianthum; Solanaceae; root; solanerianone; norsesquiterpenoid; sesquiterpenoid; spirovetivene; anti-inflammatory; cytotoxicity
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MDPI and ACS Style
Chen, Y.-C.; Lee, H.-Z.; Chen, H.-C.; Wen, C.-L.; Kuo, Y.-H.; Wang, G.-J. Anti-Inflammatory Components from the Root of Solanum erianthum. Int. J. Mol. Sci. 2013, 14, 12581-12592.
Chen Y-C, Lee H-Z, Chen H-C, Wen C-L, Kuo Y-H, Wang G-J. Anti-Inflammatory Components from the Root of Solanum erianthum. International Journal of Molecular Sciences. 2013; 14(6):12581-12592.
Chen, Yu-Chang; Lee, Hong-Zin; Chen, Hsin-Chun; Wen, Chi-Luan; Kuo, Yueh-Hsiung; Wang, Guei-Jane. 2013. "Anti-Inflammatory Components from the Root of Solanum erianthum." Int. J. Mol. Sci. 14, no. 6: 12581-12592.