Abstract: Two new norsesquiterpenoids, solanerianones A and B (1–2), together with nine known compounds, including four sesquiterpenoids, (−)-solavetivone (3), (+)-anhydro-β-rotunol (4), solafuranone (5), lycifuranone A (6); one alkaloid, N-trans-feruloyltyramine (7); one fatty acid, palmitic acid (8); one phenylalkanoid, acetovanillone (9), and two steroids, β-sitosterol (10) and stigmasterol (11) were isolated from the n-hexane-soluble part of the roots of Solanum erianthum. Their structures were elucidated on the basis of physical and spectroscopic data analyses. The anti-inflammatory activity of these isolates was monitored by nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells. The cytotoxicity towards human lung squamous carcinoma (CH27), human hepatocellular carcinoma (Hep 3B), human oral squamous carcinoma (HSC-3) and human melanoma (M21) cell lines was also screened by using an MTT assay. Of the compounds tested, 3 exhibited the strongest NO inhibition with the average maximum inhibition (Emax) at 100 μM and median inhibitory concentration (IC50) values of 98.23% ± 0.08% and 65.54 ± 0.18 μM, respectively. None of compounds (1–9) was found to possess cytotoxic activity against human cancer cell lines at concentrations up to 30 μM.
Keywords: Solanum erianthum; Solanaceae; root; solanerianone; norsesquiterpenoid; sesquiterpenoid; spirovetivene; anti-inflammatory; cytotoxicity
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Chen, Y.-C.; Lee, H.-Z.; Chen, H.-C.; Wen, C.-L.; Kuo, Y.-H.; Wang, G.-J. Anti-Inflammatory Components from the Root of Solanum erianthum. Int. J. Mol. Sci. 2013, 14, 12581-12592.
Chen Y-C, Lee H-Z, Chen H-C, Wen C-L, Kuo Y-H, Wang G-J. Anti-Inflammatory Components from the Root of Solanum erianthum. International Journal of Molecular Sciences. 2013; 14(6):12581-12592.
Chen, Yu-Chang; Lee, Hong-Zin; Chen, Hsin-Chun; Wen, Chi-Luan; Kuo, Yueh-Hsiung; Wang, Guei-Jane. 2013. "Anti-Inflammatory Components from the Root of Solanum erianthum." Int. J. Mol. Sci. 14, no. 6: 12581-12592.