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Int. J. Mol. Sci. 2013, 14(6), 12581-12592; doi:10.3390/ijms140612581
Article

Anti-Inflammatory Components from the Root of Solanum erianthum

1,* , 2
, 3
, 4
, 1,5
 and 6,7,*
Received: 10 May 2013; in revised form: 7 June 2013 / Accepted: 13 June 2013 / Published: 14 June 2013
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: Two new norsesquiterpenoids, solanerianones A and B (12), together with nine known compounds, including four sesquiterpenoids, (−)-solavetivone (3), (+)-anhydro-β-rotunol (4), solafuranone (5), lycifuranone A (6); one alkaloid, N-trans-feruloyltyramine (7); one fatty acid, palmitic acid (8); one phenylalkanoid, acetovanillone (9), and two steroids, β-sitosterol (10) and stigmasterol (11) were isolated from the n-hexane-soluble part of the roots of Solanum erianthum. Their structures were elucidated on the basis of physical and spectroscopic data analyses. The anti-inflammatory activity of these isolates was monitored by nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells. The cytotoxicity towards human lung squamous carcinoma (CH27), human hepatocellular carcinoma (Hep 3B), human oral squamous carcinoma (HSC-3) and human melanoma (M21) cell lines was also screened by using an MTT assay. Of the compounds tested, 3 exhibited the strongest NO inhibition with the average maximum inhibition (Emax) at 100 μM and median inhibitory concentration (IC50) values of 98.23% ± 0.08% and 65.54 ± 0.18 μM, respectively. None of compounds (19) was found to possess cytotoxic activity against human cancer cell lines at concentrations up to 30 μM.
Keywords: Solanum erianthum; Solanaceae; root; solanerianone; norsesquiterpenoid; sesquiterpenoid; spirovetivene; anti-inflammatory; cytotoxicity Solanum erianthum; Solanaceae; root; solanerianone; norsesquiterpenoid; sesquiterpenoid; spirovetivene; anti-inflammatory; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, Y.-C.; Lee, H.-Z.; Chen, H.-C.; Wen, C.-L.; Kuo, Y.-H.; Wang, G.-J. Anti-Inflammatory Components from the Root of Solanum erianthum. Int. J. Mol. Sci. 2013, 14, 12581-12592.

AMA Style

Chen Y-C, Lee H-Z, Chen H-C, Wen C-L, Kuo Y-H, Wang G-J. Anti-Inflammatory Components from the Root of Solanum erianthum. International Journal of Molecular Sciences. 2013; 14(6):12581-12592.

Chicago/Turabian Style

Chen, Yu-Chang; Lee, Hong-Zin; Chen, Hsin-Chun; Wen, Chi-Luan; Kuo, Yueh-Hsiung; Wang, Guei-Jane. 2013. "Anti-Inflammatory Components from the Root of Solanum erianthum." Int. J. Mol. Sci. 14, no. 6: 12581-12592.



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