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Int. J. Mol. Sci. 2013, 14(6), 11238-11258; doi:10.3390/ijms140611238
Review

Astrocytic Vesicle Mobility in Health and Disease

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Received: 1 April 2013; in revised form: 26 April 2013 / Accepted: 8 May 2013 / Published: 27 May 2013
(This article belongs to the Special Issue Regulation of Membrane Trafficking and Its Potential Implications)
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Abstract: Astrocytes are no longer considered subservient to neurons, and are, instead, now understood to play an active role in brain signaling. The intercellular communication of astrocytes with neurons and other non-neuronal cells involves the exchange of molecules by exocytotic and endocytotic processes through the trafficking of intracellular vesicles. Recent studies of single vesicle mobility in astrocytes have prompted new views of how astrocytes contribute to information processing in nervous tissue. Here, we review the trafficking of several types of membrane-bound vesicles that are specifically involved in the processes of (i) intercellular communication by gliotransmitters (glutamate, adenosine 5'-triphosphate, atrial natriuretic peptide), (ii) plasma membrane exchange of transporters and receptors (EAAT2, MHC-II), and (iii) the involvement of vesicle mobility carrying aquaporins (AQP4) in water homeostasis. The properties of vesicle traffic in astrocytes are discussed in respect to networking with neighboring cells in physiologic and pathologic conditions, such as amyotrophic lateral sclerosis, multiple sclerosis, and states in which astrocytes contribute to neuroinflammatory conditions.
Keywords: astrocyte; glia; vesicle; trafficking; gliotransmitter; antigen presentation; neuroinflammation; amyotrophic lateral sclerosis; multiple sclerosis astrocyte; glia; vesicle; trafficking; gliotransmitter; antigen presentation; neuroinflammation; amyotrophic lateral sclerosis; multiple sclerosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Potokar, M.; Vardjan, N.; Stenovec, M.; Gabrijel, M.; Trkov, S.; Jorgačevski, J.; Kreft, M.; Zorec, R. Astrocytic Vesicle Mobility in Health and Disease. Int. J. Mol. Sci. 2013, 14, 11238-11258.

AMA Style

Potokar M, Vardjan N, Stenovec M, Gabrijel M, Trkov S, Jorgačevski J, Kreft M, Zorec R. Astrocytic Vesicle Mobility in Health and Disease. International Journal of Molecular Sciences. 2013; 14(6):11238-11258.

Chicago/Turabian Style

Potokar, Maja; Vardjan, Nina; Stenovec, Matjaž; Gabrijel, Mateja; Trkov, Saša; Jorgačevski, Jernej; Kreft, Marko; Zorec, Robert. 2013. "Astrocytic Vesicle Mobility in Health and Disease." Int. J. Mol. Sci. 14, no. 6: 11238-11258.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert