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Int. J. Mol. Sci. 2013, 14(5), 9319-9337; doi:10.3390/ijms14059319

Effects of Nanotoxicity on Female Reproductivity and Fetal Development in Animal Models

Received: 28 February 2013 / Revised: 17 April 2013 / Accepted: 18 April 2013 / Published: 29 April 2013
(This article belongs to the Special Issue Bioactive Nanoparticles 2013)
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The extensive application of nanomaterials in industry, medicine and consumer products has raised concerns about their potential toxicity. The female population is particularly vulnerable and deserves special attention because toxicity in this group may impact both female reproductivity and fetal development. Mouse and zebrafish models each have their own unique features and studies using these models to examine the potential toxicity of various nanoparticles are compared and summarized in this review. Several nanoparticles exhibit detrimental effects on female reproductivity as well as fetal development, and these adverse effects are related to nanoparticle composition, surface modification, dose, exposure route and animal species. Limited studies on the mechanisms of nanotoxicity are also documented and reviewed herein.
Keywords: nanotoxicity; reproductivity; development; animal model; zebrafish nanotoxicity; reproductivity; development; animal model; zebrafish
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sun, J.; Zhang, Q.; Wang, Z.; Yan, B. Effects of Nanotoxicity on Female Reproductivity and Fetal Development in Animal Models. Int. J. Mol. Sci. 2013, 14, 9319-9337.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert