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Effects of Nanotoxicity on Female Reproductivity and Fetal Development in Animal Models
School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
School of Public Health, Shandong University, Jinan 250100, China
* Author to whom correspondence should be addressed.
Received: 28 February 2013; in revised form: 17 April 2013 / Accepted: 18 April 2013 / Published: 29 April 2013
Abstract: The extensive application of nanomaterials in industry, medicine and consumer products has raised concerns about their potential toxicity. The female population is particularly vulnerable and deserves special attention because toxicity in this group may impact both female reproductivity and fetal development. Mouse and zebrafish models each have their own unique features and studies using these models to examine the potential toxicity of various nanoparticles are compared and summarized in this review. Several nanoparticles exhibit detrimental effects on female reproductivity as well as fetal development, and these adverse effects are related to nanoparticle composition, surface modification, dose, exposure route and animal species. Limited studies on the mechanisms of nanotoxicity are also documented and reviewed herein.
Keywords: nanotoxicity; reproductivity; development; animal model; zebrafish
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Cite This Article
MDPI and ACS Style
Sun, J.; Zhang, Q.; Wang, Z.; Yan, B. Effects of Nanotoxicity on Female Reproductivity and Fetal Development in Animal Models. Int. J. Mol. Sci. 2013, 14, 9319-9337.
Sun J, Zhang Q, Wang Z, Yan B. Effects of Nanotoxicity on Female Reproductivity and Fetal Development in Animal Models. International Journal of Molecular Sciences. 2013; 14(5):9319-9337.
Sun, Jianling; Zhang, Qiu; Wang, Zhiping; Yan, Bing. 2013. "Effects of Nanotoxicity on Female Reproductivity and Fetal Development in Animal Models." Int. J. Mol. Sci. 14, no. 5: 9319-9337.