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Int. J. Mol. Sci. 2013, 14(5), 9168-9181; doi:10.3390/ijms14059168

The Effect of the Aerial Part of Lindera akoensis on Lipopolysaccharides (LPS)-Induced Nitric Oxide Production in RAW264.7 Cells

1
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
2
Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
3
Department of Forestry, National Chung Hsing University, Taichung 402, Taiwan
4
Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan
5
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
6
The Experimental Forest Management Office, National Chung-Hsing University, Taichung 402, Taiwan
7
Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 402, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 12 March 2013 / Revised: 12 April 2013 / Accepted: 15 April 2013 / Published: 26 April 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Four new secondary metabolites, 3α-((E)-Dodec-1-enyl)-4β-hydroxy-5β-methyldihydrofuran-2-one (1), linderinol (6), 4'-O-methylkaempferol 3-O-α-L-(4''-E-p-coumaroyl)rhamnoside (11) and kaempferol 3-O-α-L-(4''-Z-p-coumaroyl)rhamnoside (12) with eleven known compounds—3-epilistenolide D1 (2), 3-epilistenolide D2 (3), (3Z,4α,5β)-3-(dodec-11-ynylidene)-4-hydroxy-5-methylbutanolide (4), (3E,4β,5β)-3-(dodec-11-ynylidene)-4-hydroxy-5-methylbutanolide (5), matairesinol (7), syringaresinol (8), (+)-pinoresinol (9), salicifoliol (10), 4''-p-coumaroylafzelin (13), catechin (14) and epicatechin (15)—were first isolated from the aerial part of Lindera akoensis. Their structures were determined by detailed analysis of 1D- and 2D-NMR spectroscopic data. All of the compounds isolated from Lindera akoensis showed that in vitro anti-inflammatory activity decreases the LPS-stimulated production of nitric oxide (NO) in RAW 264.7 cell, with IC50 values of 4.1–413.8 µM.
Keywords: Chinese herb; Lindera akoensis; butanolide; lignans; flavonoids; anti-inflammatory Chinese herb; Lindera akoensis; butanolide; lignans; flavonoids; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Yang, C.-P.; Huang, G.-J.; Huang, H.-C.; Chen, Y.-C.; Chang, C.-I.; Wang, S.-Y.; Chang, H.-S.; Tseng, Y.-H.; Chien, S.-C.; Kuo, Y.-H. The Effect of the Aerial Part of Lindera akoensis on Lipopolysaccharides (LPS)-Induced Nitric Oxide Production in RAW264.7 Cells. Int. J. Mol. Sci. 2013, 14, 9168-9181.

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