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Int. J. Mol. Sci. 2013, 14(5), 8890-8898; doi:10.3390/ijms14058890
Article

Triterpenoids from the Roots of Rhaphiolepis indica var. tashiroi and Their Anti-Inflammatory Activity

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Received: 22 February 2013 / Revised: 22 March 2013 / Accepted: 26 March 2013 / Published: 24 April 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Two new triterpenoids, 2α,3β-dihydroxyolean-11,13(18)-dien-19β,28-olide (1) and 3β,5β-dihydroxyglutinol (2), together with eight known compounds (310) were isolated from the roots of Rhaphiolepis indica var. tashiroi (Rosaceae). The structures of 110 were determined by spectroscopic techniques. Among these isolates, 2α,3β-dihydroxyolean-13(18)-en-28-oic acid (9) exhibited inhibitory effect on N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production, with an IC50 value of 16.50 μM.
Keywords: Rhaphiolepis indica var. tashiroi; Rosaceae; roots; triterpenoids; anti-inflammatory activity; inhibition of superoxide production Rhaphiolepis indica var. tashiroi; Rosaceae; roots; triterpenoids; anti-inflammatory activity; inhibition of superoxide production
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lin, C.-H.; Chang, H.-S.; Liao, H.-R.; Chen, I.-S.; Tsai, I.-L. Triterpenoids from the Roots of Rhaphiolepis indica var. tashiroi and Their Anti-Inflammatory Activity. Int. J. Mol. Sci. 2013, 14, 8890-8898.

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