Int. J. Mol. Sci. 2013, 14(5), 8890-8898; doi:10.3390/ijms14058890
Article

Triterpenoids from the Roots of Rhaphiolepis indica var. tashiroi and Their Anti-Inflammatory Activity

1 School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan 2 Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan 3 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 33302, Taiwan
* Author to whom correspondence should be addressed.
Received: 22 February 2013; in revised form: 22 March 2013 / Accepted: 26 March 2013 / Published: 24 April 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: Two new triterpenoids, 2α,3β-dihydroxyolean-11,13(18)-dien-19β,28-olide (1) and 3β,5β-dihydroxyglutinol (2), together with eight known compounds (310) were isolated from the roots of Rhaphiolepis indica var. tashiroi (Rosaceae). The structures of 110 were determined by spectroscopic techniques. Among these isolates, 2α,3β-dihydroxyolean-13(18)-en-28-oic acid (9) exhibited inhibitory effect on N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production, with an IC50 value of 16.50 μM.
Keywords: Rhaphiolepis indica var. tashiroi; Rosaceae; roots; triterpenoids; anti-inflammatory activity; inhibition of superoxide production

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MDPI and ACS Style

Lin, C.-H.; Chang, H.-S.; Liao, H.-R.; Chen, I.-S.; Tsai, I.-L. Triterpenoids from the Roots of Rhaphiolepis indica var. tashiroi and Their Anti-Inflammatory Activity. Int. J. Mol. Sci. 2013, 14, 8890-8898.

AMA Style

Lin C-H, Chang H-S, Liao H-R, Chen I-S, Tsai I-L. Triterpenoids from the Roots of Rhaphiolepis indica var. tashiroi and Their Anti-Inflammatory Activity. International Journal of Molecular Sciences. 2013; 14(5):8890-8898.

Chicago/Turabian Style

Lin, Chu-Hung; Chang, Hsun-Shuo; Liao, Hsiang-Ruei; Chen, Ih-Sheng; Tsai, Ian-Lih. 2013. "Triterpenoids from the Roots of Rhaphiolepis indica var. tashiroi and Their Anti-Inflammatory Activity." Int. J. Mol. Sci. 14, no. 5: 8890-8898.

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