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Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection
Laboratory of Cancer Biology, Department of Medical Oncology, Institute of Clinical Science, Sir Runrun Shaw Hospital, Medical School of Zhejiang University, Hangzhou 310029, China
* Author to whom correspondence should be addressed.
Received: 11 March 2013; in revised form: 1 April 2013 / Accepted: 25 April 2013 / Published: 16 May 2013
Abstract: Epigenetic alterations including DNA methylation and microRNAs (miRNAs) play important roles in the initiation and progression of human cancers. As the extensively studied epigenetic changes in tumors, DNA methylation and miRNAs are the most potential epigenetic biomarkers for cancer diagnosis. After the identification of circulating cell-free nuclear acids, increasing evidence demonstrated great potential of cell-free epigenetic biomarkers in the blood or other body fluids for cancer detection.
Keywords: cancer; biomarker; DNA methylation; miRNAs
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Ma, Y.; Wang, X.; Jin, H. Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection. Int. J. Mol. Sci. 2013, 14, 10307-10331.
Ma Y, Wang X, Jin H. Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection. International Journal of Molecular Sciences. 2013; 14(5):10307-10331.
Ma, Yanning; Wang, Xian; Jin, Hongchuan. 2013. "Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection." Int. J. Mol. Sci. 14, no. 5: 10307-10331.