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Int. J. Mol. Sci. 2013, 14(5), 10307-10331; doi:10.3390/ijms140510307

Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection

Laboratory of Cancer Biology, Department of Medical Oncology, Institute of Clinical Science, Sir Runrun Shaw Hospital, Medical School of Zhejiang University, Hangzhou 310029, China
* Author to whom correspondence should be addressed.
Received: 11 March 2013 / Revised: 1 April 2013 / Accepted: 25 April 2013 / Published: 16 May 2013
(This article belongs to the Special Issue Advances in Cancer Diagnosis)
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Epigenetic alterations including DNA methylation and microRNAs (miRNAs) play important roles in the initiation and progression of human cancers. As the extensively studied epigenetic changes in tumors, DNA methylation and miRNAs are the most potential epigenetic biomarkers for cancer diagnosis. After the identification of circulating cell-free nuclear acids, increasing evidence demonstrated great potential of cell-free epigenetic biomarkers in the blood or other body fluids for cancer detection.
Keywords: cancer; biomarker; DNA methylation; miRNAs cancer; biomarker; DNA methylation; miRNAs
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ma, Y.; Wang, X.; Jin, H. Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection. Int. J. Mol. Sci. 2013, 14, 10307-10331.

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