Int. J. Mol. Sci. 2013, 14(4), 7716-7741; doi:10.3390/ijms14047716

Sphingomyelin in High-Density Lipoproteins: Structural Role and Biological Function

1,2email, 2,3email, 2email and 1,2,* email
Received: 19 February 2013; in revised form: 20 March 2013 / Accepted: 29 March 2013 / Published: 9 April 2013
(This article belongs to the Special Issue Phospholipids: Molecular Sciences 2012)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: High-density lipoprotein (HDL) levels are an inverse risk factor for cardiovascular diseases, and sphingomyelin (SM) is the second most abundant phospholipid component and the major sphingolipid in HDL. Considering the marked presence of SM, the present review has focused on the current knowledge about this phospholipid by addressing its variable distribution among HDL lipoparticles, how they acquire this phospholipid, and the important role that SM plays in regulating their fluidity and cholesterol efflux from different cells. In addition, plasma enzymes involved in HDL metabolism such as lecithin–cholesterol acyltransferase or phospholipid transfer protein are inhibited by HDL SM content. Likewise, HDL SM levels are influenced by dietary maneuvers (source of protein or fat), drugs (statins or diuretics) and modified in diseases such as diabetes, renal failure or Niemann–Pick disease. Furthermore, increased levels of HDL SM have been shown to be an inverse risk factor for coronary heart disease. The complexity of SM species, described using new lipidomic methodologies, and their distribution in different HDL particles under many experimental conditions are promising avenues for further research in the future.
Keywords: high-density lipoproteins; phospholipids; sphingomyelin
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MDPI and ACS Style

Martínez-Beamonte, R.; Lou-Bonafonte, J.M.; Martínez-Gracia, M.V.; Osada, J. Sphingomyelin in High-Density Lipoproteins: Structural Role and Biological Function. Int. J. Mol. Sci. 2013, 14, 7716-7741.

AMA Style

Martínez-Beamonte R, Lou-Bonafonte JM, Martínez-Gracia MV, Osada J. Sphingomyelin in High-Density Lipoproteins: Structural Role and Biological Function. International Journal of Molecular Sciences. 2013; 14(4):7716-7741.

Chicago/Turabian Style

Martínez-Beamonte, Roberto; Lou-Bonafonte, Jose M.; Martínez-Gracia, María V.; Osada, Jesús. 2013. "Sphingomyelin in High-Density Lipoproteins: Structural Role and Biological Function." Int. J. Mol. Sci. 14, no. 4: 7716-7741.

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