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Int. J. Mol. Sci. 2013, 14(4), 6649-6673; doi:10.3390/ijms14046649
Review

Diacylglycerol Kinases: Regulated Controllers of T Cell Activation, Function, and Development

1
 and
1,2,*
1 Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA 2 Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
* Author to whom correspondence should be addressed.
Received: 1 February 2013 / Revised: 7 March 2013 / Accepted: 14 March 2013 / Published: 26 March 2013
(This article belongs to the Special Issue Signalling Molecules and Signal Transduction in Cells)
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Abstract

Diacylglycerol kinases (DGKs) are a diverse family of enzymes that catalyze the conversion of diacylglycerol (DAG), a crucial second messenger of receptor-mediated signaling, to phosphatidic acid (PA). Both DAG and PA are bioactive molecules that regulate a wide set of intracellular signaling proteins involved in innate and adaptive immunity. Clear evidence points to a critical role for DGKs in modulating T cell activation, function, and development. More recently, studies have elucidated factors that control DGK function, suggesting an added complexity to how DGKs act during signaling. This review summarizes the available knowledge of the function and regulation of DGK isoforms in signal transduction with a particular focus on T lymphocytes.
Keywords: diacylglycerol kinase; DGK; signal transduction; T cells; iNKT cells; anergy; tumor immunity diacylglycerol kinase; DGK; signal transduction; T cells; iNKT cells; anergy; tumor immunity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Joshi, R.P.; Koretzky, G.A. Diacylglycerol Kinases: Regulated Controllers of T Cell Activation, Function, and Development. Int. J. Mol. Sci. 2013, 14, 6649-6673.

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