- freely available
UPR Signal Activation by Luminal Sensor Domains
AbstractThe unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis. The presence of unfolded protein is detected by the ER-luminal sensor domains of the three UPR-transducer proteins IRE1, PERK, and ATF6, which then propagate the signal to the cytosol. In this review, we discuss the various mechanisms of action that have been proposed on how the sensor domains detect the presence of unfolded protein to activate downstream UPR signaling.
Share & Cite This Article
Carrara, M.; Prischi, F.; Ali, M.M.U. UPR Signal Activation by Luminal Sensor Domains. Int. J. Mol. Sci. 2013, 14, 6454-6466.View more citation formats
Carrara M, Prischi F, Ali MMU. UPR Signal Activation by Luminal Sensor Domains. International Journal of Molecular Sciences. 2013; 14(3):6454-6466.Chicago/Turabian Style
Carrara, Marta; Prischi, Filippo; Ali, Maruf M.U. 2013. "UPR Signal Activation by Luminal Sensor Domains." Int. J. Mol. Sci. 14, no. 3: 6454-6466.