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UPR Signal Activation by Luminal Sensor Domains
Department of Life Sciences, Centre for Structural Biology, Imperial College London, London SW7 2AZ, UK
* Author to whom correspondence should be addressed.
Received: 30 January 2013; in revised form: 15 March 2013 / Accepted: 18 March 2013 / Published: 21 March 2013
Abstract: The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis. The presence of unfolded protein is detected by the ER-luminal sensor domains of the three UPR-transducer proteins IRE1, PERK, and ATF6, which then propagate the signal to the cytosol. In this review, we discuss the various mechanisms of action that have been proposed on how the sensor domains detect the presence of unfolded protein to activate downstream UPR signaling.
Keywords: unfolded protein response; ER-stress; signaling
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Cite This Article
MDPI and ACS Style
Carrara, M.; Prischi, F.; Ali, M.M.U. UPR Signal Activation by Luminal Sensor Domains. Int. J. Mol. Sci. 2013, 14, 6454-6466.
Carrara M, Prischi F, Ali MMU. UPR Signal Activation by Luminal Sensor Domains. International Journal of Molecular Sciences. 2013; 14(3):6454-6466.
Carrara, Marta; Prischi, Filippo; Ali, Maruf M.U. 2013. "UPR Signal Activation by Luminal Sensor Domains." Int. J. Mol. Sci. 14, no. 3: 6454-6466.