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• Brou, C
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Int. J. Mol. Sci. 2013, 14(3), 6359-6381; doi:10.3390/ijms14036359

Review

Ubiquitinations in the Notch Signaling Pathway

Julien Moretti ¹  and Christel Brou ^2,*

¹ Immunology Institute, Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA ² Institut Pasteur and CNRS URA 2582, Signalisation Moléculaire et Activation Cellulaire, 25 rue du Docteur Roux, 75724 Paris cedex 15, France

* Author to whom correspondence should be addressed.

Received: 1 February 2013; in revised form: 11 March 2013 / Accepted: 14 March 2013 / Published: 19 March 2013

(This article belongs to the Special Issue Signalling Molecules and Signal Transduction in Cells)

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Abstract: The very conserved Notch pathway is used iteratively during development and adulthood to regulate cell fates. Notch activation relies on interactions between neighboring cells, through the binding of Notch receptors to their ligands, both transmembrane molecules. This inter-cellular contact initiates a cascade of events eventually transforming the cell surface receptor into a nuclear factor acting on the transcription of specific target genes. This review highlights how the various processes undergone by Notch receptors and ligands that regulate the pathway are linked to ubiquitination events.

Keywords: Notch; ubiquitination; deubiquitinating enzyme; signal transduction; trafficking

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