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Int. J. Mol. Sci. 2013, 14(3), 6359-6381; doi:10.3390/ijms14036359
Review

Ubiquitinations in the Notch Signaling Pathway

1
 and 2,*
Received: 1 February 2013; in revised form: 11 March 2013 / Accepted: 14 March 2013 / Published: 19 March 2013
(This article belongs to the Special Issue Signalling Molecules and Signal Transduction in Cells)
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Abstract: The very conserved Notch pathway is used iteratively during development and adulthood to regulate cell fates. Notch activation relies on interactions between neighboring cells, through the binding of Notch receptors to their ligands, both transmembrane molecules. This inter-cellular contact initiates a cascade of events eventually transforming the cell surface receptor into a nuclear factor acting on the transcription of specific target genes. This review highlights how the various processes undergone by Notch receptors and ligands that regulate the pathway are linked to ubiquitination events.
Keywords: Notch; ubiquitination; deubiquitinating enzyme; signal transduction; trafficking Notch; ubiquitination; deubiquitinating enzyme; signal transduction; trafficking
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Moretti, J.; Brou, C. Ubiquitinations in the Notch Signaling Pathway. Int. J. Mol. Sci. 2013, 14, 6359-6381.

AMA Style

Moretti J, Brou C. Ubiquitinations in the Notch Signaling Pathway. International Journal of Molecular Sciences. 2013; 14(3):6359-6381.

Chicago/Turabian Style

Moretti, Julien; Brou, Christel. 2013. "Ubiquitinations in the Notch Signaling Pathway." Int. J. Mol. Sci. 14, no. 3: 6359-6381.


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