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Ubiquitinations in the Notch Signaling Pathway
AbstractThe very conserved Notch pathway is used iteratively during development and adulthood to regulate cell fates. Notch activation relies on interactions between neighboring cells, through the binding of Notch receptors to their ligands, both transmembrane molecules. This inter-cellular contact initiates a cascade of events eventually transforming the cell surface receptor into a nuclear factor acting on the transcription of specific target genes. This review highlights how the various processes undergone by Notch receptors and ligands that regulate the pathway are linked to ubiquitination events.
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Moretti, J.; Brou, C. Ubiquitinations in the Notch Signaling Pathway. Int. J. Mol. Sci. 2013, 14, 6359-6381.View more citation formats
Moretti J, Brou C. Ubiquitinations in the Notch Signaling Pathway. International Journal of Molecular Sciences. 2013; 14(3):6359-6381.Chicago/Turabian Style
Moretti, Julien; Brou, Christel. 2013. "Ubiquitinations in the Notch Signaling Pathway." Int. J. Mol. Sci. 14, no. 3: 6359-6381.