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The Lipid Transfer Protein StarD7: Structure, Function, and Regulation
Universidad Nacional de Córdoba-Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Químicas, Departamento de Bioquímica Clínica-Centro de Investigaciones en Bioquímica Clínica e Inmunología, X5000HUA Córdoba, Argentina
* Author to whom correspondence should be addressed.
Received: 7 December 2012; in revised form: 17 February 2013 / Accepted: 22 February 2013 / Published: 18 March 2013
Abstract: The steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain proteins constitute a family of evolutionarily conserved and widely expressed proteins that have been implicated in lipid transport, metabolism, and signaling. The 15 well-characterized mammalian START domain-containing proteins are grouped into six subfamilies. The START domain containing 7 mRNA encodes StarD7, a member of the StarD2/phosphatidylcholine transfer protein (PCTP) subfamily, which was first identified as a gene overexpressed in a choriocarcinoma cell line. Recent studies show that the StarD7 protein facilitates the delivery of phosphatidylcholine to the mitochondria. This review summarizes the latest advances in StarD7 research, focusing on the structural and biochemical features, protein-lipid interactions, and mechanisms that regulate StarD7 expression. The implications of the role of StarD7 in cell proliferation, migration, and differentiation are also discussed.
Keywords: StarD7; START domain; SF-1; b-catenin; ABCG2; cell migration; cell proliferation
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Flores-Martin, J.; Rena, V.; Angeletti, S.; Panzetta-Dutari, G.M.; Genti-Raimondi, S. The Lipid Transfer Protein StarD7: Structure, Function, and Regulation. Int. J. Mol. Sci. 2013, 14, 6170-6186.
Flores-Martin J, Rena V, Angeletti S, Panzetta-Dutari GM, Genti-Raimondi S. The Lipid Transfer Protein StarD7: Structure, Function, and Regulation. International Journal of Molecular Sciences. 2013; 14(3):6170-6186.
Flores-Martin, Jésica; Rena, Viviana; Angeletti, Sofía; Panzetta-Dutari, Graciela M.; Genti-Raimondi, Susana. 2013. "The Lipid Transfer Protein StarD7: Structure, Function, and Regulation." Int. J. Mol. Sci. 14, no. 3: 6170-6186.