Int. J. Mol. Sci. 2013, 14(3), 5734-5749; doi:10.3390/ijms14035734
Review

Structural Biology of a Major Signaling Network that Regulates Plant Abiotic Stress: The CBL-CIPK Mediated Pathway

María José Sánchez-Barrenaemail, Martín Martínez-Ripollemail and Armando Albert* email
Department of Crystallography and Structural Biology, Instituto de Química Física "Rocasolano", Consejo Superior de Investigaciones Científicas, Serrano 119, Madrid E-28006, Spain
* Author to whom correspondence should be addressed.
Received: 31 January 2013; in revised form: 27 February 2013 / Accepted: 28 February 2013 / Published: 12 March 2013
(This article belongs to the Special Issue Abiotic and Biotic Stress Tolerance Mechanisms in Plants)
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Abstract: The Arabidopsis SOS2 family of twenty-six protein kinases (CIPKs), their interacting activators, the SOS3 family of ten calcium-binding proteins (CBLs) and protein phosphatases type 2C (PP2C), function together in decoding calcium signals elicited by different environmental stimuli. Biochemical data suggest that stable CBL-CIPK or CIPK-PP2C complexes may be regulating the activity of various substrates controlling ion homeostasis. The available structural information provides a general regulatory mechanism in which calcium perception by CBLs and kinase activation is coupled. The structural basis of this molecular mechanism and the specificity of the network is reviewed and discussed in detail.
Keywords: protein kinases; calmodulin-like calcium sensor; protein structure; plant abiotic stress; ion homeostasis

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MDPI and ACS Style

Sánchez-Barrena, M.J.; Martínez-Ripoll, M.; Albert, A. Structural Biology of a Major Signaling Network that Regulates Plant Abiotic Stress: The CBL-CIPK Mediated Pathway. Int. J. Mol. Sci. 2013, 14, 5734-5749.

AMA Style

Sánchez-Barrena MJ, Martínez-Ripoll M, Albert A. Structural Biology of a Major Signaling Network that Regulates Plant Abiotic Stress: The CBL-CIPK Mediated Pathway. International Journal of Molecular Sciences. 2013; 14(3):5734-5749.

Chicago/Turabian Style

Sánchez-Barrena, María J.; Martínez-Ripoll, Martín; Albert, Armando. 2013. "Structural Biology of a Major Signaling Network that Regulates Plant Abiotic Stress: The CBL-CIPK Mediated Pathway." Int. J. Mol. Sci. 14, no. 3: 5734-5749.

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