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Int. J. Mol. Sci. 2013, 14(3), 5587-5607; doi:10.3390/ijms14035587
Review

MicroRNAs Involved in Anti-Tumour Immunity

1,* , 1
 and
2
1 Department of Health Technology and Informatics, the Hong Kong Polytechnic University, Hong Kong, China 2 Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong, China
* Author to whom correspondence should be addressed.
Received: 30 October 2012 / Revised: 26 November 2012 / Accepted: 19 February 2013 / Published: 11 March 2013
(This article belongs to the Special Issue Advances in Molecular Oncology (special issue))
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Abstract

MicroRNAs (miRNAs) are a category of small RNAs that constitute a new layer of complexity to gene regulation within the cell, which has provided new perspectives in understanding cancer biology. The deregulation of miRNAs contributes critically to the development and pathophysiology of a number of cancers. miRNAs have been found to participate in cell transformation and multiplication by acting as tumour oncogenes or suppressors; therefore, harnessing miRNAs may provide promising cancer therapeutics. Another major function of miRNAs is their activity as critical regulatory vehicles eliciting important regulatory processes in anti-tumour immunity through their influence on the development, differentiation and activation of various immune cells of both innate and adaptive immunity. This review aims to summarise recent findings focusing on the regulatory mechanisms of the development, differentiation, and proliferative aspects of the major immune populations by a diverse profile of miRNAs and may enrich our current understanding of the involvement of miRNAs in anti-tumour immunity.
Keywords: anti-tumour; immunity; microRNA anti-tumour; immunity; microRNA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yu, H.W.H.; Sze, D.M.Y.; Cho, W.C.S. MicroRNAs Involved in Anti-Tumour Immunity. Int. J. Mol. Sci. 2013, 14, 5587-5607.

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