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Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer’s Disease
Department of Pathogen Biology, Medical College, Henan University of Science and Technology, Luoyang 471023, China
Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College, Beijing 100021, China
* Author to whom correspondence should be addressed.
Received: 20 December 2012; in revised form: 4 February 2013 / Accepted: 16 February 2013 / Published: 11 March 2013
Abstract: The Amyloid-β (Aβ)-induced impairment of hippocampal synaptic plasticity is an underlying mechanism of memory loss in the early stages of Alzheimer's disease (AD) in human and mouse models. The inhibition of the calcium/calmodulin-dependent protein kinase II (CaMKII) autophosphorylation plays an important role in long-term memory. In this study, we isolated naringin from Pomelo peel (a Citrus species) and studied its effect on long-term memory in the APPswe/PS1dE9 transgenic mouse model of AD. Three-month-old APPswe/PS1dE9 transgenic mice were randomly assigned to a vehicle group, two naringin (either 50 or 100 mg/kg body weight/day) groups, or an Aricept (2 mg/kg body weight/day) group. After 16 weeks of treatment, we observed that treatment with naringin (100 mg/kg body weight/day) enhanced the autophosphorylation of CaMKII, increased the phosphorylation of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic (AMPA) receptor at a CaMKII-dependent site and improved long-term learning and memory ability. These findings suggest that the increase in CaMKII activity may be one of the mechanisms by which naringin improves long-term cognitive function in the APPswe/PS1dE9 transgenic mouse model of AD.
Keywords: Naringin; Alzheimer’s disease; APPswe/PS1dE9 mice; CaMKII
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MDPI and ACS Style
Wang, D.-M.; Yang, Y.-J.; Zhang, L.; Zhang, X.; Guan, F.-F.; Zhang, L.-F. Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer’s Disease. Int. J. Mol. Sci. 2013, 14, 5576-5586.
Wang D-M, Yang Y-J, Zhang L, Zhang X, Guan F-F, Zhang L-F. Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer’s Disease. International Journal of Molecular Sciences. 2013; 14(3):5576-5586.
Wang, Dong-Mei; Yang, Ya-Jun; Zhang, Li; Zhang, Xu; Guan, Fei-Fei; Zhang, Lian-Feng. 2013. "Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer’s Disease." Int. J. Mol. Sci. 14, no. 3: 5576-5586.