Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer’s Disease
Abstract
:1. Introduction
2. Results and Discussion
2.1. Naringin Delays the Passive-Avoidance Decline of APPswe/PS1dE9 Mice in a Step-Through Test
2.2. Naringin Improves Long-Term Learning and Memory of APPswe/PS1dE9 Mice in the Morris Water Maze
2.3. Naringin Enhances CaMKII Activity in an AD Model
3. Experimental Section
3.1. Isolation of Naringin
3.2. APPswe/PS1dE9 Mice and Naringin Treatment
3.3. Passive-Avoidance Test
3.4. Morris Water Maze
3.5. Tissue Preparation
3.6. Western Blot Analysis
3.7. Immunofluorescence Staining
3.8. Statistical Analysis
4. Conclusions
Acknowledgments
References
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Wang, D.-M.; Yang, Y.-J.; Zhang, L.; Zhang, X.; Guan, F.-F.; Zhang, L.-F. Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer’s Disease. Int. J. Mol. Sci. 2013, 14, 5576-5586. https://doi.org/10.3390/ijms14035576
Wang D-M, Yang Y-J, Zhang L, Zhang X, Guan F-F, Zhang L-F. Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer’s Disease. International Journal of Molecular Sciences. 2013; 14(3):5576-5586. https://doi.org/10.3390/ijms14035576
Chicago/Turabian StyleWang, Dong-Mei, Ya-Jun Yang, Li Zhang, Xu Zhang, Fei-Fei Guan, and Lian-Feng Zhang. 2013. "Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer’s Disease" International Journal of Molecular Sciences 14, no. 3: 5576-5586. https://doi.org/10.3390/ijms14035576