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Natural Products as a Source for Treating Neglected Parasitic Diseases
Department of Biological Sciences, Faculty of Science, University of Ngaoundere, B. P. 454, Cameroon
Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Science, University of São Paulo, Av. Prof. Lineu Prestes 1374, 05508-000 São Paulo-SP, Brazil
Institute for Zoophysiology, Schlossplatz 8, D-48143 Münster, Germany
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 21 December 2012; in revised form: 12 January 2013 / Accepted: 16 January 2013 / Published: 6 February 2013
Abstract: Infectious diseases caused by parasites are a major threat for the entire mankind, especially in the tropics. More than 1 billion people world-wide are directly exposed to tropical parasites such as the causative agents of trypanosomiasis, leishmaniasis, schistosomiasis, lymphatic filariasis and onchocerciasis, which represent a major health problem, particularly in impecunious areas. Unlike most antibiotics, there is no “general” antiparasitic drug available. Here, the selection of antiparasitic drugs varies between different organisms. Some of the currently available drugs are chemically de novo synthesized, however, the majority of drugs are derived from natural sources such as plants which have subsequently been chemically modified to warrant higher potency against these human pathogens. In this review article we will provide an overview of the current status of plant derived pharmaceuticals and their chemical modifications to target parasite-specific peculiarities in order to interfere with their proliferation in the human host.
Keywords: neglected infectious diseases; natural compounds; schistosomiasis; river blindness; trypanosomatids
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Ndjonka, D.; Rapado, L.N.; Silber, A.M.; Liebau, E.; Wrenger, C. Natural Products as a Source for Treating Neglected Parasitic Diseases. Int. J. Mol. Sci. 2013, 14, 3395-3439.
Ndjonka D, Rapado LN, Silber AM, Liebau E, Wrenger C. Natural Products as a Source for Treating Neglected Parasitic Diseases. International Journal of Molecular Sciences. 2013; 14(2):3395-3439.
Ndjonka, Dieudonné; Rapado, Ludmila N.; Silber, Ariel M.; Liebau, Eva; Wrenger, Carsten. 2013. "Natural Products as a Source for Treating Neglected Parasitic Diseases." Int. J. Mol. Sci. 14, no. 2: 3395-3439.