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Int. J. Mol. Sci. 2013, 14(2), 3395-3439; doi:10.3390/ijms14023395
Review

Natural Products as a Source for Treating Neglected Parasitic Diseases

1,†
, 2,†
, 2
, 3,*  and 2,*
Received: 21 December 2012; in revised form: 12 January 2013 / Accepted: 16 January 2013 / Published: 6 February 2013
(This article belongs to the Special Issue Plant-Derived Pharmaceuticals by Molecular Farming 2012)
Abstract: Infectious diseases caused by parasites are a major threat for the entire mankind, especially in the tropics. More than 1 billion people world-wide are directly exposed to tropical parasites such as the causative agents of trypanosomiasis, leishmaniasis, schistosomiasis, lymphatic filariasis and onchocerciasis, which represent a major health problem, particularly in impecunious areas. Unlike most antibiotics, there is no “general” antiparasitic drug available. Here, the selection of antiparasitic drugs varies between different organisms. Some of the currently available drugs are chemically de novo synthesized, however, the majority of drugs are derived from natural sources such as plants which have subsequently been chemically modified to warrant higher potency against these human pathogens. In this review article we will provide an overview of the current status of plant derived pharmaceuticals and their chemical modifications to target parasite-specific peculiarities in order to interfere with their proliferation in the human host.
Keywords: neglected infectious diseases; natural compounds; schistosomiasis; river blindness; trypanosomatids neglected infectious diseases; natural compounds; schistosomiasis; river blindness; trypanosomatids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ndjonka, D.; Rapado, L.N.; Silber, A.M.; Liebau, E.; Wrenger, C. Natural Products as a Source for Treating Neglected Parasitic Diseases. Int. J. Mol. Sci. 2013, 14, 3395-3439.

AMA Style

Ndjonka D, Rapado LN, Silber AM, Liebau E, Wrenger C. Natural Products as a Source for Treating Neglected Parasitic Diseases. International Journal of Molecular Sciences. 2013; 14(2):3395-3439.

Chicago/Turabian Style

Ndjonka, Dieudonné; Rapado, Ludmila N.; Silber, Ariel M.; Liebau, Eva; Wrenger, Carsten. 2013. "Natural Products as a Source for Treating Neglected Parasitic Diseases." Int. J. Mol. Sci. 14, no. 2: 3395-3439.



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