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Int. J. Mol. Sci. 2013, 14(2), 3050-3064; doi:10.3390/ijms14023050
Article

Sodium Dodecyl Sulfate (SDS)-Loaded Nanoporous Polymer as Anti-Biofilm Surface Coating Material

1
, 2
, 2,3,4,*  and 5,*
1 Danish Polymer Centre, Department of Chemical and Biochemical Engineering, Technical University of Denmark, Kgs. Lyngby DK-2800, Denmark 2 Department of Systems Biology, Technical University of Denmark, Kgs. Lyngby DK-2800, Denmark 3 Singapore Centre on Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore 637551, Singapore 4 School of Biological Sciences, Nanyang Technological University, Singapore 639798, Singapore 5 Department of Micro and Nanotechnology, Technical University of Denmark, Kgs. Lyngby DK-2800, Denmark
* Authors to whom correspondence should be addressed.
Received: 18 January 2013 / Revised: 25 January 2013 / Accepted: 29 January 2013 / Published: 1 February 2013
(This article belongs to the Special Issue Antimicrobial Polymers)
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Abstract

Biofilms cause extensive damage to industrial settings. Thus, it is important to improve the existing techniques and develop new strategies to prevent bacterial biofilm formation. In the present study, we have prepared nanoporous polymer films from a self-assembled 1,2-polybutadiene-b-polydimethylsiloxane (1,2-PB-b-PDMS) block copolymer via chemical cross-linking of the 1,2-PB block followed by quantitative removal of the PDMS block. Sodium dodecyl sulfate (SDS) was loaded into the nanoporous 1,2-PB from aqueous solution. The SDS-loaded nanoporous polymer films were shown to block bacterial attachment in short-term (3 h) and significantly reduce biofilm formation in long-term (1 week) by gram-negative bacterium Escherichia coli. Tuning the thickness or surface morphology of the nanoporous polymer films allowed to extent the anti-biofilm capability.
Keywords: nanoporous polymer; SDS; biofilm; Escherichia coli nanoporous polymer; SDS; biofilm; Escherichia coli
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, L.; Molin, S.; Yang, L.; Ndoni, S. Sodium Dodecyl Sulfate (SDS)-Loaded Nanoporous Polymer as Anti-Biofilm Surface Coating Material. Int. J. Mol. Sci. 2013, 14, 3050-3064.

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