Int. J. Mol. Sci. 2013, 14(12), 23369-23389; doi:10.3390/ijms141223369

Design, Synthesis and Cytotoxic Evaluation of o-Carboxamido Stilbene Analogues

1email, 1email, 1email, 1email, 1email, 2email, 2email, 1email, 3email, 3email and 1,* email
Received: 15 July 2013; in revised form: 13 September 2013 / Accepted: 17 September 2013 / Published: 27 November 2013
(This article belongs to the Section Bioactives and Nutraceuticals)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Resveratrol, a natural stilbene found in grapes and wines exhibits a wide range of pharmacological properties. Resveratrol is also known as a good chemopreventive agent for inhibiting carcinogenesis processes that target kinases, cyclooxygenases, ribonucleotide reductase and DNA polymerases. A total of 19 analogues with an amide moiety were synthesized and the cytotoxic effects of the analogues on a series of human cancer cell lines are reported. Three compounds 6d, 6i and 6n showed potent cytotoxicity against prostate cancer DU-145 (IC50 = 16.68 µM), colon cancer HT-29 (IC50 = 7.51 µM) and breast cancer MCF-7 (IC50 = 21.24 µM), respectively, which are comparable with vinblastine. The resveratrol analogues were synthesized using the Heck method.
Keywords: o-carboxamido stilbenes; amido stilbenes; Heck protocol; cytotoxic effects
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MDPI and ACS Style

Azmi, M.N.; Din, M.F.M.; Kee, C.H.; Suhaimi, M.; Ping, A.K.; Ahmad, K.; Nafiah, M.A.; Thomas, N.F.; Mohamad, K.; Hoong, L.K.; Awang, K. Design, Synthesis and Cytotoxic Evaluation of o-Carboxamido Stilbene Analogues. Int. J. Mol. Sci. 2013, 14, 23369-23389.

AMA Style

Azmi MN, Din MFM, Kee CH, Suhaimi M, Ping AK, Ahmad K, Nafiah MA, Thomas NF, Mohamad K, Hoong LK, Awang K. Design, Synthesis and Cytotoxic Evaluation of o-Carboxamido Stilbene Analogues. International Journal of Molecular Sciences. 2013; 14(12):23369-23389.

Chicago/Turabian Style

Azmi, Mohamad N.; Din, Mohd F.M.; Kee, Chin H.; Suhaimi, Munirah; Ping, Ang K.; Ahmad, Kartini; Nafiah, Mohd A.; Thomas, Noel F.; Mohamad, Khalit; Hoong, Leong K.; Awang, Khalijah. 2013. "Design, Synthesis and Cytotoxic Evaluation of o-Carboxamido Stilbene Analogues." Int. J. Mol. Sci. 14, no. 12: 23369-23389.

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