Next Article in Journal
Regenerative Medicine for Epilepsy: From Basic Research to Clinical Application
Previous Article in Journal
Modification of Pectin and Hemicellulose Polysaccharides in Relation to Aril Breakdown of Harvested Longan Fruit
Int. J. Mol. Sci. 2013, 14(12), 23369-23389; doi:10.3390/ijms141223369
Article

Design, Synthesis and Cytotoxic Evaluation of o-Carboxamido Stilbene Analogues

1
, 1
, 1
, 1
, 1
, 2
, 2
, 1
, 3
, 3
 and 1,*
1 Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia 2 Department of Chemistry, Faculty of Science and Mathematics, Sultan Azlan Shah Campus, University Pendidikan Sultan Idris, Proton City 35950, Perak Darul Ridzuan, Malaysia 3 Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur 50603, Malaysia
* Author to whom correspondence should be addressed.
Received: 15 July 2013 / Revised: 13 September 2013 / Accepted: 17 September 2013 / Published: 27 November 2013
(This article belongs to the Section Bioactives and Nutraceuticals)
View Full-Text   |   Download PDF [732 KB, uploaded 19 June 2014]   |   Browse Figures

Abstract

Resveratrol, a natural stilbene found in grapes and wines exhibits a wide range of pharmacological properties. Resveratrol is also known as a good chemopreventive agent for inhibiting carcinogenesis processes that target kinases, cyclooxygenases, ribonucleotide reductase and DNA polymerases. A total of 19 analogues with an amide moiety were synthesized and the cytotoxic effects of the analogues on a series of human cancer cell lines are reported. Three compounds 6d, 6i and 6n showed potent cytotoxicity against prostate cancer DU-145 (IC50 = 16.68 µM), colon cancer HT-29 (IC50 = 7.51 µM) and breast cancer MCF-7 (IC50 = 21.24 µM), respectively, which are comparable with vinblastine. The resveratrol analogues were synthesized using the Heck method.
Keywords: o-carboxamido stilbenes; amido stilbenes; Heck protocol; cytotoxic effects o-carboxamido stilbenes; amido stilbenes; Heck protocol; cytotoxic effects
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Azmi, M.N.; Din, M.F.M.; Kee, C.H.; Suhaimi, M.; Ping, A.K.; Ahmad, K.; Nafiah, M.A.; Thomas, N.F.; Mohamad, K.; Hoong, L.K.; Awang, K. Design, Synthesis and Cytotoxic Evaluation of o-Carboxamido Stilbene Analogues. Int. J. Mol. Sci. 2013, 14, 23369-23389.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert