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Int. J. Mol. Sci. 2013, 14(11), 21833-21857; doi:10.3390/ijms141121833
Review

Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis

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Received: 27 August 2013; in revised form: 14 October 2013 / Accepted: 21 October 2013 / Published: 4 November 2013
(This article belongs to the Special Issue Non-Alcoholic Fatty Liver Disease Research)
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Abstract: Research in nonalcoholic fatty liver disease (NAFLD), including nonalcoholic steatohepatitis (NASH), has been limited by the availability of suitable models for this disease. A number of rodent models have been described in which the relevant liver pathology develops in an appropriate metabolic context. These models are promising tools for researchers investigating one of the key issues of NASH: not so much why steatosis occurs, but what causes the transition from simple steatosis to the inflammatory, progressive fibrosing condition of steatohepatitis. The different rodent models can be classified into two large groups. The first includes models in which the disease is acquired after dietary or pharmacological manipulation, and the second, genetically modified models in which liver disease develops spontaneously. To date, no single rodent model has encompassed the full spectrum of human disease progression, but individual models can imitate particular characteristics of human disease. Therefore, it is important that researchers choose the appropriate rodent models. The purpose of the present review is to discuss the metabolic abnormalities present in the currently available rodent models of NAFLD, summarizing the strengths and weaknesses of the established models and the key findings that have furthered our understanding of the disease’s pathogenesis.
Keywords: NAFLD; NASH; animal model; rodent model NAFLD; NASH; animal model; rodent model
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Imajo, K.; Yoneda, M.; Kessoku, T.; Ogawa, Y.; Maeda, S.; Sumida, Y.; Hyogo, H.; Eguchi, Y.; Wada, K.; Nakajima, A. Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis. Int. J. Mol. Sci. 2013, 14, 21833-21857.

AMA Style

Imajo K, Yoneda M, Kessoku T, Ogawa Y, Maeda S, Sumida Y, Hyogo H, Eguchi Y, Wada K, Nakajima A. Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis. International Journal of Molecular Sciences. 2013; 14(11):21833-21857.

Chicago/Turabian Style

Imajo, Kento; Yoneda, Masato; Kessoku, Takaomi; Ogawa, Yuji; Maeda, Shin; Sumida, Yoshio; Hyogo, Hideyuki; Eguchi, Yuichiro; Wada, Koichiro; Nakajima, Atsushi. 2013. "Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis." Int. J. Mol. Sci. 14, no. 11: 21833-21857.


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