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Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
Department of Gastroenterology, Yokohama City University Graduate School of Medicine, 3-9 Fuku-ura, Yokohama 236-0004, Japan
Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan
Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, Japan
Department of Internal Medicine, Saga Medical School, Saga University, Saga 849-8501, Japan
Department of Pharmacology, Osaka University Graduate School of Dentistry, 1-8 Yamada-oka, Suita 565-0871, Japan
* Author to whom correspondence should be addressed.
Received: 27 August 2013; in revised form: 14 October 2013 / Accepted: 21 October 2013 / Published: 4 November 2013
Abstract: Research in nonalcoholic fatty liver disease (NAFLD), including nonalcoholic steatohepatitis (NASH), has been limited by the availability of suitable models for this disease. A number of rodent models have been described in which the relevant liver pathology develops in an appropriate metabolic context. These models are promising tools for researchers investigating one of the key issues of NASH: not so much why steatosis occurs, but what causes the transition from simple steatosis to the inflammatory, progressive fibrosing condition of steatohepatitis. The different rodent models can be classified into two large groups. The first includes models in which the disease is acquired after dietary or pharmacological manipulation, and the second, genetically modified models in which liver disease develops spontaneously. To date, no single rodent model has encompassed the full spectrum of human disease progression, but individual models can imitate particular characteristics of human disease. Therefore, it is important that researchers choose the appropriate rodent models. The purpose of the present review is to discuss the metabolic abnormalities present in the currently available rodent models of NAFLD, summarizing the strengths and weaknesses of the established models and the key findings that have furthered our understanding of the disease’s pathogenesis.
Keywords: NAFLD; NASH; animal model; rodent model
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Imajo, K.; Yoneda, M.; Kessoku, T.; Ogawa, Y.; Maeda, S.; Sumida, Y.; Hyogo, H.; Eguchi, Y.; Wada, K.; Nakajima, A. Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis. Int. J. Mol. Sci. 2013, 14, 21833-21857.
Imajo K, Yoneda M, Kessoku T, Ogawa Y, Maeda S, Sumida Y, Hyogo H, Eguchi Y, Wada K, Nakajima A. Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis. International Journal of Molecular Sciences. 2013; 14(11):21833-21857.
Imajo, Kento; Yoneda, Masato; Kessoku, Takaomi; Ogawa, Yuji; Maeda, Shin; Sumida, Yoshio; Hyogo, Hideyuki; Eguchi, Yuichiro; Wada, Koichiro; Nakajima, Atsushi. 2013. "Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis." Int. J. Mol. Sci. 14, no. 11: 21833-21857.