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Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis
Francesco Balsano Foundation, via G.B. Martini 6, Rome 00198, Italy
Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Via Tronto 10, Ancona 60020, Italy
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini n.6, Florence 50139, Italy
Institute of Molecular Biology and Pathology (IBPM)-National Research Council (CNR), Piazzale Aldo Moro 7, Rome 00185, Italy
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 2 September 2013; in revised form: 18 October 2013 / Accepted: 24 October 2013 / Published: 7 November 2013
Abstract: The liver is crucial for human life, and the health of this organ often mirrors the health of the individual. The liver can be the target of several diseases, the most prevalent of which, as a consequence of development and changes in human lifestyles, is the nonalcoholic fatty liver disease (NAFLD). NAFLD is a multifactorial disease that embraces many histo-pathologic conditions and is highly linked to metabolic derangements. Technological progress and industrialization have also had the consequence of releasing pollutants in the environment, for instance pesticides or solvents, as well as by-products of discharge, such as the particulate matter. In the last decade, a growing body of evidence has emerged, shedding light on the potential impact of environmental pollutants on liver health and, in particular, on NAFLD occurrence. These contaminants have a great steatogenic potential and need to be considered as tangible NAFLD risk factors. There is an urgent need for a deeper comprehension of their molecular mechanisms of action, as well as for new lines of intervention to reduce their worldwide diffusion. This review wishes to sensitize the community to the effects of several environmental pollutants on liver health.
Keywords: environment; pollution; contaminants; particulate matter; chemicals; metals; endocrine disruptors; liver; NAFLD; nonalcoholic steatohepatitis (NASH)
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Arciello, M.; Gori, M.; Maggio, R.; Barbaro, B.; Tarocchi, M.; Galli, A.; Balsano, C. Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis. Int. J. Mol. Sci. 2013, 14, 22052-22066.
Arciello M, Gori M, Maggio R, Barbaro B, Tarocchi M, Galli A, Balsano C. Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis. International Journal of Molecular Sciences. 2013; 14(11):22052-22066.
Arciello, Mario; Gori, Manuele; Maggio, Roberta; Barbaro, Barbara; Tarocchi, Mirko; Galli, Andrea; Balsano, Clara. 2013. "Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis." Int. J. Mol. Sci. 14, no. 11: 22052-22066.