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Int. J. Mol. Sci. 2013, 14(11), 22052-22066; doi:10.3390/ijms141122052
Review

Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis

1,†
, 1,2,†
, 1
, 1
, 3
, 3
 and 1,4,*
Received: 2 September 2013; in revised form: 18 October 2013 / Accepted: 24 October 2013 / Published: 7 November 2013
(This article belongs to the Special Issue Non-Alcoholic Fatty Liver Disease Research)
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Abstract: The liver is crucial for human life, and the health of this organ often mirrors the health of the individual. The liver can be the target of several diseases, the most prevalent of which, as a consequence of development and changes in human lifestyles, is the nonalcoholic fatty liver disease (NAFLD). NAFLD is a multifactorial disease that embraces many histo-pathologic conditions and is highly linked to metabolic derangements. Technological progress and industrialization have also had the consequence of releasing pollutants in the environment, for instance pesticides or solvents, as well as by-products of discharge, such as the particulate matter. In the last decade, a growing body of evidence has emerged, shedding light on the potential impact of environmental pollutants on liver health and, in particular, on NAFLD occurrence. These contaminants have a great steatogenic potential and need to be considered as tangible NAFLD risk factors. There is an urgent need for a deeper comprehension of their molecular mechanisms of action, as well as for new lines of intervention to reduce their worldwide diffusion. This review wishes to sensitize the community to the effects of several environmental pollutants on liver health.
Keywords: environment; pollution; contaminants; particulate matter; chemicals; metals; endocrine disruptors; liver; NAFLD; nonalcoholic steatohepatitis (NASH) environment; pollution; contaminants; particulate matter; chemicals; metals; endocrine disruptors; liver; NAFLD; nonalcoholic steatohepatitis (NASH)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Arciello, M.; Gori, M.; Maggio, R.; Barbaro, B.; Tarocchi, M.; Galli, A.; Balsano, C. Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis. Int. J. Mol. Sci. 2013, 14, 22052-22066.

AMA Style

Arciello M, Gori M, Maggio R, Barbaro B, Tarocchi M, Galli A, Balsano C. Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis. International Journal of Molecular Sciences. 2013; 14(11):22052-22066.

Chicago/Turabian Style

Arciello, Mario; Gori, Manuele; Maggio, Roberta; Barbaro, Barbara; Tarocchi, Mirko; Galli, Andrea; Balsano, Clara. 2013. "Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis." Int. J. Mol. Sci. 14, no. 11: 22052-22066.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert