Int. J. Mol. Sci. 2013, 14(11), 21489-21503; doi:10.3390/ijms141121489
Article

NF-κB-Targeted Anti-Inflammatory Activity of Prunella vulgaris var. lilacina in Macrophages RAW 264.7

Received: 24 August 2013; in revised form: 29 September 2013 / Accepted: 23 October 2013 / Published: 30 October 2013
(This article belongs to the Section Bioactives and Nutraceuticals)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Prunella vulgaris var. lilacina, a herbal medicine, has long been used in Korea for the treatment of sore throat, and to alleviate fever and accelerate wound healing. Although the therapeutic effect of P. vulgaris var. lilacina is likely associated with anti-inflammatory activity, the precise underlying mechanisms are largely unknown. Here, we sought to elucidate the possible mechanisms of the anti-inflammatory activity. We have investigated the anti-inflammatory activity of the various solvent fractions (hexane, butanol, chloroform and water) from the ethanol extract of P. vulgaris var. lilacina in activated macrophages. The hexane fraction exhibited higher anti-inflammatory activities, inducing inhibition of nitric oxide and prostaglandin E2 production as well as inducible nitric oxide synthase, cyclooxygenase-2, and tumor necrosis factor-α mRNA expression in response to lipopolysaccharide stimulation. Moreover, the hexane fraction from P. vulgaris var. lilacina significantly inhibited the activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and the nuclear translocation of the NF-κB p50 and p65 subunits. These results indicate that P. vulgaris var. lilacina has an anti-inflammatory capacity in vitro, suggesting that it could be a potential source of natural anti-inflammatory agents.
Keywords: Prunella vulgaris var. lilacina; anti-inflammation; NO; PGE2; NF-κB
PDF Full-text Download PDF Full-Text [912 KB, uploaded 19 June 2014 05:14 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Hwang, Y.-J.; Lee, E.-J.; Kim, H.-R.; Hwang, K.-A. NF-κB-Targeted Anti-Inflammatory Activity of Prunella vulgaris var. lilacina in Macrophages RAW 264.7. Int. J. Mol. Sci. 2013, 14, 21489-21503.

AMA Style

Hwang Y-J, Lee E-J, Kim H-R, Hwang K-A. NF-κB-Targeted Anti-Inflammatory Activity of Prunella vulgaris var. lilacina in Macrophages RAW 264.7. International Journal of Molecular Sciences. 2013; 14(11):21489-21503.

Chicago/Turabian Style

Hwang, Yu-Jin; Lee, Eun-Ju; Kim, Haeng-Ran; Hwang, Kyung-A. 2013. "NF-κB-Targeted Anti-Inflammatory Activity of Prunella vulgaris var. lilacina in Macrophages RAW 264.7." Int. J. Mol. Sci. 14, no. 11: 21489-21503.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert