Int. J. Mol. Sci. 2013, 14(10), 20930-20953; doi:10.3390/ijms141020930
Review

MicroRNA-Regulated Pathways in Hematological Malignancies: How to Avoid Cells Playing Out of Tune

1,†,* email and 2,†,* email
Received: 31 July 2013; in revised form: 3 October 2013 / Accepted: 10 October 2013 / Published: 18 October 2013
(This article belongs to the Special Issue Molecular Bases of Cancer Research)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The coordinated expression and interplay among lineage specific transcription factors and microRNAs contribute to the regulation of gene expression and determination of cell specificity. In hematopoietic stem cells (HSCs), unique combinations of transcription factors largely control growth and maturation of different blood cell lineages through cooperative regulation of specific target genes. MicroRNAs provide an additional level of control beyond transcription factors. By acting as regulators of crucial lineage-specific genetic programs, microRNAs direct early multipotential progenitor cells to adopt a certain cell fate program. Thus, alteration of specific microRNA levels may affect proliferation, differentiation and genetic stability of HSCs, contributing to the onset of myeloproliferative disorders and leukemia. The major aim of this review is to highlight the critical role of microRNA-regulated pathways during the establishment and progression of hematological malignancies, with a particular attention to leukemia, lymphomas and myelodysplastic syndromes. This will give us the opportunity to discuss the potential use of microRNA-based therapeutic approaches in these diseases. MicroRNAs are indeed emerging as relevant tools to improve the efficacy of currently used therapeutic protocols.
Keywords: microRNA; leukemia; lymphoma
PDF Full-text Download PDF Full-Text [402 KB, uploaded 19 June 2014 05:13 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Fatica, A.; Fazi, F. MicroRNA-Regulated Pathways in Hematological Malignancies: How to Avoid Cells Playing Out of Tune. Int. J. Mol. Sci. 2013, 14, 20930-20953.

AMA Style

Fatica A, Fazi F. MicroRNA-Regulated Pathways in Hematological Malignancies: How to Avoid Cells Playing Out of Tune. International Journal of Molecular Sciences. 2013; 14(10):20930-20953.

Chicago/Turabian Style

Fatica, Alessandro; Fazi, Francesco. 2013. "MicroRNA-Regulated Pathways in Hematological Malignancies: How to Avoid Cells Playing Out of Tune." Int. J. Mol. Sci. 14, no. 10: 20930-20953.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert