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Int. J. Mol. Sci. 2013, 14(10), 20459-20477; doi:10.3390/ijms141020459
Article

Twist and miR-34a Are Involved in the Generation of Tumor-Educated Myeloid-Derived Suppressor Cells

1,2,†
, 3,†
, 4,†
, 5,*  and 1,*
1 Department of General Surgery, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China 2 Department of Gynaecology and Obstetrics, the 306 Hospital of PLA, Beijing 100037, China 3 Department of General Surgery, Yancheng City First People's Hospital, Yancheng City 224000, Jiangsu, China 4 Department of Colorectal Surgery, the Second Artillery General Hospital of PLA, Beijing 10008, China 5 Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai 200433, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 7 July 2013 / Revised: 19 September 2013 / Accepted: 23 September 2013 / Published: 14 October 2013
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Abstract

Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor cells in the tumor microenvironment, contributing to tumor immunological escapes. Many studies have demonstrated that multiple factors could induce myeloid precursor cells into myeloid-derived suppressor cells, not dendritic cells. In our study, we found that tumor supernatants could induce the generation of myeloid-derived suppressor cells by disturbing the development of dendritic cells. Twist and miR-34a may regulate the effect of tumor cells inducing myeloid-derived suppressor cells via TGF-β and/or IL-10.
Keywords: myeloid-derived suppressor cells; twist; miR-34a; dendritic cells; tumor escape myeloid-derived suppressor cells; twist; miR-34a; dendritic cells; tumor escape
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wang, X.; Chang, X.; Zhuo, G.; Sun, M.; Yin, K. Twist and miR-34a Are Involved in the Generation of Tumor-Educated Myeloid-Derived Suppressor Cells. Int. J. Mol. Sci. 2013, 14, 20459-20477.

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