Next Article in Journal
Previous Article in Journal
Int. J. Mol. Sci. 2013, 14(10), 20459-20477; doi:10.3390/ijms141020459
Article

Twist and miR-34a Are Involved in the Generation of Tumor-Educated Myeloid-Derived Suppressor Cells

1,2,†
, 3,†
, 4,†
, 5,*  and 1,*
Received: 7 July 2013; in revised form: 19 September 2013 / Accepted: 23 September 2013 / Published: 14 October 2013
View Full-Text   |   Download PDF [3436 KB, uploaded 19 June 2014]   |   Browse Figures
Abstract: Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor cells in the tumor microenvironment, contributing to tumor immunological escapes. Many studies have demonstrated that multiple factors could induce myeloid precursor cells into myeloid-derived suppressor cells, not dendritic cells. In our study, we found that tumor supernatants could induce the generation of myeloid-derived suppressor cells by disturbing the development of dendritic cells. Twist and miR-34a may regulate the effect of tumor cells inducing myeloid-derived suppressor cells via TGF-β and/or IL-10.
Keywords: myeloid-derived suppressor cells; twist; miR-34a; dendritic cells; tumor escape myeloid-derived suppressor cells; twist; miR-34a; dendritic cells; tumor escape
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Wang, X.; Chang, X.; Zhuo, G.; Sun, M.; Yin, K. Twist and miR-34a Are Involved in the Generation of Tumor-Educated Myeloid-Derived Suppressor Cells. Int. J. Mol. Sci. 2013, 14, 20459-20477.

AMA Style

Wang X, Chang X, Zhuo G, Sun M, Yin K. Twist and miR-34a Are Involved in the Generation of Tumor-Educated Myeloid-Derived Suppressor Cells. International Journal of Molecular Sciences. 2013; 14(10):20459-20477.

Chicago/Turabian Style

Wang, Xin; Chang, Xusheng; Zhuo, Guangzuan; Sun, Mingjuan; Yin, Kai. 2013. "Twist and miR-34a Are Involved in the Generation of Tumor-Educated Myeloid-Derived Suppressor Cells." Int. J. Mol. Sci. 14, no. 10: 20459-20477.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert