Int. J. Mol. Sci. 2013, 14(10), 19361-19384; doi:10.3390/ijms141019361
Review

EGFR-Ras-Raf Signaling in Epidermal Stem Cells: Roles in Hair Follicle Development, Regeneration, Tissue Remodeling and Epidermal Cancers

Max. F. Perutz Laboratories, Department of Microbiology, Immunology and Genetics, University of Vienna, Doktor-Bohr-Gasse 9, 1030 Vienna, Austria These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 11 July 2013; in revised form: 12 September 2013 / Accepted: 17 September 2013 / Published: 25 September 2013
(This article belongs to the Special Issue Molecular Research of Epidermal Stem Cells)
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Abstract: The mammalian skin is the largest organ of the body and its outermost layer, the epidermis, undergoes dynamic lifetime renewal through the activity of somatic stem cell populations. The EGFR-Ras-Raf pathway has a well-described role in skin development and tumor formation. While research mainly focuses on its role in cutaneous tumor initiation and maintenance, much less is known about Ras signaling in the epidermal stem cells, which are the main targets of skin carcinogenesis. In this review, we briefly discuss the properties of the epidermal stem cells and review the role of EGFR-Ras-Raf signaling in keratinocyte stem cells during homeostatic and pathological conditions.
Keywords: epidermis; hair follicle; stem cell; EGFR signaling; Ras; Raf; SSC; BCC; wound healing

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MDPI and ACS Style

Doma, E.; Rupp, C.; Baccarini, M. EGFR-Ras-Raf Signaling in Epidermal Stem Cells: Roles in Hair Follicle Development, Regeneration, Tissue Remodeling and Epidermal Cancers. Int. J. Mol. Sci. 2013, 14, 19361-19384.

AMA Style

Doma E, Rupp C, Baccarini M. EGFR-Ras-Raf Signaling in Epidermal Stem Cells: Roles in Hair Follicle Development, Regeneration, Tissue Remodeling and Epidermal Cancers. International Journal of Molecular Sciences. 2013; 14(10):19361-19384.

Chicago/Turabian Style

Doma, Eszter; Rupp, Christian; Baccarini, Manuela. 2013. "EGFR-Ras-Raf Signaling in Epidermal Stem Cells: Roles in Hair Follicle Development, Regeneration, Tissue Remodeling and Epidermal Cancers." Int. J. Mol. Sci. 14, no. 10: 19361-19384.

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