Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Int. J. Mol. Sci. 2013, 14(10), 19361-19384; doi:10.3390/ijms141019361
Review

EGFR-Ras-Raf Signaling in Epidermal Stem Cells: Roles in Hair Follicle Development, Regeneration, Tissue Remodeling and Epidermal Cancers

,
 and *
Received: 11 July 2013; in revised form: 12 September 2013 / Accepted: 17 September 2013 / Published: 25 September 2013
(This article belongs to the Special Issue Molecular Research of Epidermal Stem Cells)
View Full-Text   |   Download PDF [532 KB, uploaded 19 June 2014]
Abstract: The mammalian skin is the largest organ of the body and its outermost layer, the epidermis, undergoes dynamic lifetime renewal through the activity of somatic stem cell populations. The EGFR-Ras-Raf pathway has a well-described role in skin development and tumor formation. While research mainly focuses on its role in cutaneous tumor initiation and maintenance, much less is known about Ras signaling in the epidermal stem cells, which are the main targets of skin carcinogenesis. In this review, we briefly discuss the properties of the epidermal stem cells and review the role of EGFR-Ras-Raf signaling in keratinocyte stem cells during homeostatic and pathological conditions.
Keywords: epidermis; hair follicle; stem cell; EGFR signaling; Ras; Raf; SSC; BCC; wound healing epidermis; hair follicle; stem cell; EGFR signaling; Ras; Raf; SSC; BCC; wound healing
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Doma, E.; Rupp, C.; Baccarini, M. EGFR-Ras-Raf Signaling in Epidermal Stem Cells: Roles in Hair Follicle Development, Regeneration, Tissue Remodeling and Epidermal Cancers. Int. J. Mol. Sci. 2013, 14, 19361-19384.

AMA Style

Doma E, Rupp C, Baccarini M. EGFR-Ras-Raf Signaling in Epidermal Stem Cells: Roles in Hair Follicle Development, Regeneration, Tissue Remodeling and Epidermal Cancers. International Journal of Molecular Sciences. 2013; 14(10):19361-19384.

Chicago/Turabian Style

Doma, Eszter; Rupp, Christian; Baccarini, Manuela. 2013. "EGFR-Ras-Raf Signaling in Epidermal Stem Cells: Roles in Hair Follicle Development, Regeneration, Tissue Remodeling and Epidermal Cancers." Int. J. Mol. Sci. 14, no. 10: 19361-19384.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert