Next Article in Journal
The DNA-Damage Response to γ-Radiation Is Affected by miR-27a in A549 Cells
Next Article in Special Issue
EGFR-Ras-Raf Signaling in Epidermal Stem Cells: Roles in Hair Follicle Development, Regeneration, Tissue Remodeling and Epidermal Cancers
Previous Article in Journal
Icariin Protects Rat Cardiac H9c2 Cells from Apoptosis by Inhibiting Endoplasmic Reticulum Stress
Previous Article in Special Issue
Cultivation of Keratinocytes and Fibroblasts in a Three-Dimensional Bovine Collagen-Elastin Matrix (Matriderm®) and Application for Full Thickness Wound Coverage in Vivo
Int. J. Mol. Sci. 2013, 14(9), 17861-17880; doi:10.3390/ijms140917861

Epidermal Stem Cells and Their Epigenetic Regulation

Department of Medical Oncology, Institute of Clinical Science, Sir Runrun Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China
* Author to whom correspondence should be addressed.
Received: 5 June 2013 / Revised: 6 August 2013 / Accepted: 15 August 2013 / Published: 30 August 2013
(This article belongs to the Special Issue Molecular Research of Epidermal Stem Cells)
View Full-Text   |   Download PDF [307 KB, uploaded 19 June 2014]   |   Browse Figure


Stem cells play an essential role in embryonic development, cell differentiation and tissue regeneration. Tissue homeostasis in adults is maintained by adult stem cells resident in the niches of different tissues. As one kind of adult stem cell, epidermal stem cells have the potential to generate diversified types of progeny cells in the skin. Although its biology is still largely unclarified, epidermal stem cells are widely used in stem cell research and regenerative medicine given its easy accessibility and pluripotency. Despite the same genome, cells within an organism have different fates due to the epigenetic regulation of gene expression. In this review, we will briefly discuss the current understanding of epigenetic modulation in epidermal stem cells.
Keywords: epidermal stem cell; epigenetic modification; histone methylation; DNA methylation; noncoding RNA; microRNA; long noncoding RNA epidermal stem cell; epigenetic modification; histone methylation; DNA methylation; noncoding RNA; microRNA; long noncoding RNA
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Shen, Q.; Jin, H.; Wang, X. Epidermal Stem Cells and Their Epigenetic Regulation. Int. J. Mol. Sci. 2013, 14, 17861-17880.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert