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Several Lipid-Related Gene Polymorphisms Interact with Overweight/Obesity to Modulate Blood Pressure Levels
Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi, China
Department of Cardiology, The Fourth Affiliated Hospital, Guangxi Medical University, Liuzhou 545005, Guangxi, China
Department of Cardiology, The Third Affiliated Hospital, Guangxi Medical University, Nanning 530000, Guangxi, China
Department of Cardiology, The People’s Hospital of Guilin, Guilin 541001, Guangxi, China
Department of Internal Medicine, Worker’s Hospital of Guangxi Liuzhou Iron and Steel (Group) Company, Liuzhou 545002, Guangxi, China
* Author to whom correspondence should be addressed.
Received: 17 August 2012; in revised form: 12 September 2012 / Accepted: 13 September 2012 / Published: 24 September 2012
Abstract: Little is known about the interactions of single nucleotide polymorphisms (SNPs) and overweight/obesity on blood pressure levels. The present study was undertaken to detect 10 lipid-related gene SNPs and their interactions with overweight/obesity on blood pressure levels. Genotyping of ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low density lipoprotein receptor (LDL-R) AvaII hepatic lipase gene (LIPC) −250G > A, endothelial lipase gene (LIPG) 584C > T, methylenetetrahydrofolate reductase (MTHFR) 677C > T, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP) rs3757354, proprotein convertase subtilisin-like kexin type 9 (PCSK9) E670G, peroxisome proliferator-activated receptor delta (PPARD) +294T > C, and Scavenger receptor class B type 1 (SCARB1) rs5888 was performed in 978 normal weight and 751 overweight/obese subjects. The interactions were detected by factorial regression analysis. The genotypes of ACAT-1 AC, LIPC GA and AA, and SCARB1 TT; LDL-R A-A- and LIPC GA; and SCARB1 TT were interacted with overweight/obesity to increase systolic, diastolic blood pressure (SBP, DBP) and pulse pressure (PP) levels; respectively. The genotypes of ACAT-1 CC; ACAT-1 AA and CC were interacted with overweight/obesity to decrease SBP, PP levels (p < 0.01–0.001); respectively. The differences in blood pressure levels between normal weight and overweight/obese subjects might partly result from different interactions of several SNPs and overweight/obesity.
Keywords: blood pressure; hypertension; genetic polymorphism; overweight; obesity; interaction
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Yin, R.-X.; Wu, D.-F.; Aung, L.H.H.; Yan, T.-T.; Cao, X.-L.; Long, X.-J.; Miao, L.; Liu, W.-Y.; Zhang, L.; Li, M. Several Lipid-Related Gene Polymorphisms Interact with Overweight/Obesity to Modulate Blood Pressure Levels. Int. J. Mol. Sci. 2012, 13, 12062-12081.
Yin R-X, Wu D-F, Aung LHH, Yan T-T, Cao X-L, Long X-J, Miao L, Liu W-Y, Zhang L, Li M. Several Lipid-Related Gene Polymorphisms Interact with Overweight/Obesity to Modulate Blood Pressure Levels. International Journal of Molecular Sciences. 2012; 13(9):12062-12081.
Yin, Rui-Xing; Wu, Dong-Feng; Aung, Lynn Htet Htet; Yan, Ting-Ting; Cao, Xiao-Li; Long, Xing-Jiang; Miao, Lin; Liu, Wan-Ying; Zhang, Lin; Li, Meng. 2012. "Several Lipid-Related Gene Polymorphisms Interact with Overweight/Obesity to Modulate Blood Pressure Levels." Int. J. Mol. Sci. 13, no. 9: 12062-12081.