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Int. J. Mol. Sci. 2012, 13(9), 11027-11043; doi:10.3390/ijms130911027

Ultrasound-Assisted Extraction of Carnosic Acid and Rosmarinic Acid Using Ionic Liquid Solution from Rosmarinus officinalis

State Engineering Laboratory for Bioresource Eco-Utilization, Northeast Forestry University, Harbin 150040, China
These authors contributed equally to this work.
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Received: 4 June 2012 / Revised: 10 August 2012 / Accepted: 14 August 2012 / Published: 5 September 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Ionic liquid based, ultrasound-assisted extraction was successfully applied to the extraction of phenolcarboxylic acids, carnosic acid and rosmarinic acid, from Rosmarinus officinalis. Eight ionic liquids, with different cations and anions, were investigated in this work and [C8mim]Br was selected as the optimal solvent. Ultrasound extraction parameters, including soaking time, solid–liquid ratio, ultrasound power and time, and the number of extraction cycles, were discussed by single factor experiments and the main influence factors were optimized by response surface methodology. The proposed approach was demonstrated as having higher efficiency, shorter extraction time and as a new alternative for the extraction of carnosic acid and rosmarinic acid from R. officinalis compared with traditional reference extraction methods. Ionic liquids are considered to be green solvents, in the ultrasound-assisted extraction of key chemicals from medicinal plants, and show great potential. View Full-Text
Keywords: Rosmarinus officinalis; carnosic acid; rosmarinic acid; ionic liquid; ultrasound-assisted extraction; response surface methodology Rosmarinus officinalis; carnosic acid; rosmarinic acid; ionic liquid; ultrasound-assisted extraction; response surface methodology
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zu, G.; Zhang, R.; Yang, L.; Ma, C.; Zu, Y.; Wang, W.; Zhao, C. Ultrasound-Assisted Extraction of Carnosic Acid and Rosmarinic Acid Using Ionic Liquid Solution from Rosmarinus officinalis. Int. J. Mol. Sci. 2012, 13, 11027-11043.

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